ArticleBiophysical journal1997
Assessment of frequency-dependent alterations in the level of extracellular Ca2+ in the synaptic cleft.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 78 citations in OpenAlex.
- Interstitial ions: A key regulator of state-dependent neural activity?Progress in neurobiology · 2020Review
- The Different Facets of Extracellular Calcium Sensors: Old and New Concepts in Calcium-Sensing Receptor Signalling and Pharmacology.International journal of molecular sciences · 2018Review
- Ionic Mechanism Underlying Rebound Depolarization in Medial Prefrontal Cortex Pyramidal Neurons.Frontiers in cellular neuroscience · 2018Article
- Molecular Basis for Modulation of Metabotropic Glutamate Receptors and Their Drug Actions by Extracellular CaInternational journal of molecular sciences · 2017Review
- The ascending median raphe projections are mainly glutamatergic in the mouse forebrain.Brain structure & function · 2016Article
- Recent advances in understanding the extracellular calcium-sensing receptor.F1000Research · 2016Review
- Calcium-Sensing Receptor: A Key Target for Extracellular Calcium Signaling in Neurons.Frontiers in physiology · 2016Review
- Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1α.The Journal of biological chemistry · 2014Article
- CALHM1 controls the Ca²⁺-dependent MEK, ERK, RSK and MSK signaling cascade in neurons.Journal of cell science · 2013Article
- Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Modulation of T cell activation by localized K⁺ accumulation at the immunological synapse--a mathematical model.Journal of theoretical biology · 2012Article
- Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1{alpha} (mGluR1{alpha}) that controls receptor activation.The Journal of biological chemistry · 2010Article
- THE ROLE OF INTRACELLULAR SODIUM (Na) IN THE REGULATION OF CALCIUM (Ca)-MEDIATED SIGNALING AND TOXICITY.Health · 2010Article
- Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Calcium-sensing receptor activation depresses synaptic transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Extracellular calcium as an integrator of tissue function.The international journal of biochemistry & cell biology · 2008Review
- Na+/Cl- dipole couples agonist binding to kainate receptor activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Use-dependent control of presynaptic calcium signalling at central synapses.Journal of anatomy · 2007Review
- Extracellular calcium regulates postsynaptic efficacy through group 1 metabotropic glutamate receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The synaptic cleft may be represented as a very thin disk of extracellular fluid. It is possible that at high stimulation frequencies the interval between pulses would be insufficient for diffusion of Ca2+ from the periphery of the cleft to replace extracellular Ca2+ depleted at the center of the cleft as a result of activation of postsynaptic, Ca2(+)-permeable channels. Computer modeling was employed to assess the impact of activation of glutamate receptor channels (GRCs) in the postsynaptic membrane on the level of extracellular Ca2+ within the synaptic cleft. The model includes calcium influx from the synaptic cleft into the postsynaptic compartment through GRC and calcium efflux through calcium pumps and Na/Ca exchangers. Concentrations of extracellular Ca2+ inside the cleft are estimated by using a compartmental model incorporating flux across the postsynaptic membrane and radial diffusion from the edges of the cleft. The simulations suggest that substantial extracellular Ca2+ depletion can occur in the clefts during activation of GRCs, particularly at high stimulation frequencies used to induce long-term potentiation (LTP). Only minimal transitory changes in extracellular Ca2+ are observed at low frequencies. These frequency-dependent alterations in extracellular Ca2+ dynamics are a direct reflection of the activity of GRCs and could be involved in the modulation of presynaptic function via a retrograde messenger mechanism, if there are extracellular Ca2+ sensors on the presynaptic membranes. The recently cloned extracellular Ca2(+)-sensing receptors that are known to be present in nerve terminals in hippocampus and other areas of the brain could potentially play such a role.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.