ReviewInternational journal of pancreatology : official journal of the International Association of Pancreatology1997
The matrix metalloproteinases and their inhibitors in pancreatic cancer. From molecular science to a clinical application.
Review in International journal of pancreatology : official journal of the International Association of Pancreatology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 107 citations in OpenAlex.
- A phase II and pharmacological study of the matrix metalloproteinase inhibitor (MMPI) COL-3 in patients with advanced soft tissue sarcomas.Investigational new drugs · 2007Trial
- Stroma Involvement in Pancreatic Ductal Adenocarcinoma: An Overview Focusing on Extracellular Matrix Proteins.Frontiers in immunology · 2021Review
- Resveratrol is a promising agent for colorectal cancer prevention and treatment: focus on molecular mechanisms.Cancer cell international · 2019Review
- Inhibition of Invasion in Pancreatic Cancer Cells by Conjugate of EPA with β(3,3)-Pip-OH via PI3K/Akt/NF-kB Pathway.ACS medicinal chemistry letters · 2015Article
- Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models.Annals of surgical oncology · 2015Article
- T11TS inhibits glioma angiogenesis by modulation of MMPs, TIMPs, with related integrin αv and TGF-β1 expressions.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.Cancer metastasis reviews · 2010Review
- Article
- Molecular biology of exocrine pancreatic cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2006Review
- Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells.Oncogene · 2003Article
- Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion.The Journal of biological chemistry · 2002Article
- Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro.Annals of the rheumatic diseases · 2002Article
- Drug development in pancreatic cancer: finally, biology begets therapy.International journal of gastrointestinal cancer · 2002Review
- Effect of combination therapy with matrix metalloproteinase inhibitor MMI-166 and mitomycin C on the growth and liver metastasis of human colon cancer.Japanese journal of cancer research : Gann · 2001Article
- Matrix metalloproteinase biology applied to vitreoretinal disorders.The British journal of ophthalmology · 2000Review
- Effect of matrix metalloproteinase inhibition on pancreatic cancer invasion and metastasis: an additive strategy for cancer control.Annals of surgery · 2000Article
- Review
- Current approaches and future strategies for pancreatic carcinoma.Investigational new drugs · 2000Review
- [Therapy of pancreatic adenocarcinoma].Medizinische Klinik (Munich, Germany : 1983) · 1999Review
- The potential for gene therapy in pancreatic cancer.International journal of pancreatology : official journal of the International Association of Pancreatology · 1999Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The matrix metalloproteinases (MMPs) and their tissue-specific inhibitors (TIMPs) are described and their roles in tumor invasion and metastasis are reviewed. The expression and activity of the MMPs and TIMPs in pancreatic cancer is reported and illustrated with immunohistochemistry and in situ hybridization. The role of MMP inhibitors (MMPIs) is reviewed in vivo and the use of novel MMPIs, e.g., BB94 (Batimastat) and BB2516 (Marimastat); in animal experiments are also described. Finally, the preliminary results from a phase 2 trial of BB2516 (Marimastat) in pancreatic cancer are reported.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.