ArticleThe Journal of experimental medicine1997
Altered hematopoiesis, behavior, and sexual function in mu opioid receptor-deficient mice.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 171 citations in OpenAlex.
- µ-Opioid Receptors Expressed by Intrinsically Photosensitive Retinal Ganglion Cells Contribute to Morphine-Induced Behavioral Sensitization.International journal of molecular sciences · 2022Article
- Exploring Pharmacological Functions of Alternatively Spliced Variants of the Mu Opioid Receptor Gene,International journal of molecular sciences · 2022Review
- Consequences of Parental Opioid Exposure on Neurophysiology, Behavior, and Health in the Next Generations.Cold Spring Harbor perspectives in medicine · 2021Review
- Roles of CatSper channels in the pathogenesis of asthenozoospermia and the therapeutic effects of acupuncture-like treatment on asthenozoospermia.Theranostics · 2021Article
- Casein and Peptides Derived from Casein as Antileukaemic Agents.Journal of oncology · 2019Review
- Usefulness of knockout mice to clarify the role of the opioid system in chronic pain.British journal of pharmacology · 2018Review
- Mediation of opioid analgesia by a truncated 6-transmembrane GPCR.The Journal of clinical investigation · 2015Article
- GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor [corrected].Scientific reports · 2015Article
- Effect of social odor context on the emission of isolation-induced ultrasonic vocalizations in the BTBR T+tf/J mouse model for autism.Frontiers in neuroscience · 2015Article
- Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies.Frontiers in pharmacology · 2015Review
- Analysis of candidate genes for morphine preference quantitative trait locus Mop2.Neuroscience · 2014Article
- Implications of genome wide association studies for addiction: are our a priori assumptions all wrong?Pharmacology & therapeutics · 2013Review
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- The endogenous opioid system in cocaine addiction: what lessons have opioid peptide and receptor knockout mice taught us?British journal of pharmacology · 2012Review
- Opioid system and Alzheimer's disease.Neuromolecular medicine · 2012Review
- Nucleus accumbens μ-opioid receptors mediate social reward.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Cross-Talk between Metabolism and Reproduction: The Role of POMC and SF1 Neurons.Frontiers in endocrinology · 2011Article
- Mice lacking the G protein gamma3-subunit show resistance to opioids and diet induced obesity.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 1 country.
Funding
Abstract
The mu opioid receptor is thought to be the cellular target of opioid narcotics such as morphine and heroin, mediating their effects in both pain relief and euphoria. Its involvement is also implicated in a range of diverse biological processes. Using a mouse model in which the receptor gene was disrupted by targeted homologous recombination, we explored the involvement of this receptor in a number of physiological functions. Mice homozygous for the disrupted gene developed normally, but their motor function was altered. Drug-naive homozygotes displayed reduced locomotor activity, and morphine did not induce changes in locomotor activity observed in wild-type mice. Unexpectedly, lack of a functional receptor resulted in changes in both the host defense system and the reproductive system. We observed increased proliferation of granulocyte-macrophage, erythroid, and multipotential progenitor cells in both bone marrow and spleen, indicating a link between hematopoiesis and the opioid system, both of which are stress-responsive systems. Unexpected changes in sexual function in male homozygotes were also observed, as shown by reduced mating activity, a decrease in sperm count and motility, and smaller litter size. Taken together, these results suggest a novel role of the mu opioid receptor in hematopoiesis and reproductive physiology, in addition to its known involvement in pain relief.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.