ArticleThe Journal of experimental medicine1997
Anti-CD43 inhibition of T cell homing.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
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Who cites it
17 citing papers in PubMed, 80 citations in OpenAlex.
- Theft and Reception of Host Cell's Sialic Acid: Dynamics ofFrontiers in immunology · 2019Review
- Increased mortality in CD43-deficient mice during sepsis.PloS one · 2018Article
- Expression of leukosialin (CD43) defines a major intrahepatic T cell subset associated with protective responses in visceral leishmaniasis.Parasites & vectors · 2015Article
- Glycosyltransferases as Markers for Early Tumorigenesis.BioMed research international · 2015Article
- CD43-mediated IFN-γ production by CD8+ T cells promotes abdominal aortic aneurysm in mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver.PLoS pathogens · 2012Article
- The initial draining lymph node primes the bulk of the CD8 T cell response and influences memory T cell trafficking after a systemic viral infection.PLoS pathogens · 2012Article
- CD43 Expression Regulated by IL-12 Signaling Is Associated with Survival of CD8 T Cells.Immune network · 2010Article
- CD43 regulates Th2 differentiation and inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Article
- Article
- High level expression of CD43 inhibits T cell receptor/CD3-mediated apoptosis.The Journal of experimental medicine · 1999Article
- Review
- CD43, a molecule with multiple functions.Immunologic research · 1999Review
- The functional paradox of CD43 in leukocyte recruitment: a study using CD43-deficient mice.The Journal of experimental medicine · 1998Article
- Molecular mechanisms of lymphocyte homing to peripheral lymph nodes.The Journal of experimental medicine · 1998Article
- Branched O-linked oligosaccharides ectopically expressed in transgenic mice reduce primary T-cell immune responses.The EMBO journal · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The homing of lymphocytes from the blood is controlled by specialized processes of lymphocyte-endothelial cell interaction. Interference with these processes offers the potential to manipulate lymphocyte traffic, and thus to modulate normal and pathologic immune and inflammatory responses. We selected antilymphocyte monoclonal antibodies (mAbs) for inhibition of lymphocyte binding in vitro to lymph node high endothelial venules (HEV), specialized vessels that support lymphocyte recruitment into lymph nodes. mAb L11 blocks T cell binding to lymph node and Peyer's patch HEV and inhibits T cell extravasation from the blood into organized secondary lymphoid tissues. In contrast, L11 has no effect on lymphocyte binding to purified vascular ligands for L-selectin, alpha4beta7, or LFA-1, suggesting that it inhibits by a novel mechanism. The L11 antigen is CD43, a sialomucin implicated in vitro in regulation of lymphocyte activation, whose expression is often dysregulated in the Wiskott-Aldrich syndrome. CD43 represents a novel target for experimental and therapeutic manipulation of lymphocyte traffic and may help regulate T cell distribution in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.