ArticleInfection and immunity1997
Growth within macrophages increases the efficiency of Mycobacterium avium in invading other macrophages by a complement receptor-independent pathway.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 89 citations in OpenAlex.
- TheMicroorganisms · 2025Review
- Systemically Administered TLR7/8 Agonist and Antigen-Conjugated Nanogels Govern Immune Responses against Tumors.ACS nano · 2022Article
- Genetic Involvement ofInternational journal of molecular sciences · 2021Review
- Roles of EvpP inFrontiers in cellular and infection microbiology · 2020Article
- PPE38 Protein ofFrontiers in cellular and infection microbiology · 2017Article
- The mechanism of cytoskeleton protein β-actin and cofilin-1 of macrophages infected by Mycobacterium avium.American journal of translational research · 2016Article
- Analysis of Ebola Virus Entry Into Macrophages.The Journal of infectious diseases · 2015Article
- Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population.BMC medical genetics · 2013Article
- Mimicry of the pathogenic mycobacterium vacuole in vitro elicits the bacterial intracellular phenotype, including early-onset macrophage death.Infection and immunity · 2011Article
- Mycobacterium avium uses apoptotic macrophages as tools for spreading.Microbial pathogenesis · 2011Article
- Mycobacterium avium infections of Acanthamoeba strains: host strain variability, grazing-acquired infections, and altered dynamics of inactivation with monochloramine.Applied and environmental microbiology · 2010Article
- The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Identification of virulence determinants of Mycobacterium avium that impact on the ability to resist host killing mechanisms.Journal of medical microbiology · 2010Article
- Phthiocerol dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids.PLoS pathogens · 2009Article
- Mycobacteria and Macrophage Apoptosis: Complex Struggle for Survival.Microbe (Washington, D.C.) · 2006Article
- Identification of Mycobacterium avium genes that affect invasion of the intestinal epithelium.Infection and immunity · 2005Article
- CD4+ T cells but Not CD8+ or gammadelta+ lymphocytes are required for host protection against Mycobacterium avium infection and dissemination through the intestinal route.Infection and immunity · 2005Article
- A subinhibitory concentration of clarithromycin inhibits Mycobacterium avium biofilm formation.Antimicrobial agents and chemotherapy · 2004Article
- Differential gene expression in mononuclear phagocytes infected with pathogenic and non-pathogenic mycobacteria.Clinical and experimental immunology · 2004Article
- Induction of apoptosis in monocytes by Mycobacterium leprae in vitro: a possible role for tumour necrosis factor-alpha.Immunology · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Infections caused by organisms of the Mycobacterium avium complex occur in approximately 50 to 60% of patients with AIDS. M. avium is an intracellular pathogen that survives and multiplies within mononuclear phagocytes. In this study, we investigated the uptake of M. avium grown within macrophages (intracellular growth M. avium [IG]) by a second macrophage compared with M. avium cultured in broth (extracellular growth M. avium [EG]). The results showed that IG was six- to eightfold more efficient than EG in entering macrophages. In addition, while an anti-CR3 antibody was able to inhibit approximately 60% of EG uptake by macrophages, it failed to inhibit the entry of IG. In contrast to EG, IG uptake into macrophages was significantly inhibited in the presence of anti-beta1-integrin and anti-transferrin receptor antibodies. Entry into macrophages by alternate receptors was associated with resistance to tumor necrosis factor alpha (TNF-alpha) stimulation. While stimulation with TNF-alpha resulted in inhibition of the growth of EG, it was not associated with inhibition of intracellular growth of IG. Investigation of the reason why M. avium is able to sense the changes in the intracellular environment triggering a change to the invasive phenotype suggests a direct relationship with macrophage apoptosis. These results suggest that intracellular growth is associated with novel mechanisms of M. avium uptake of macrophages and that those mechanisms appear to offer advantages to the bacteria in escaping the host defense.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.