ArticleInfection and immunity1997
The spv genes on the Salmonella dublin virulence plasmid are required for severe enteritis and systemic infection in the natural host.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 141 citations in OpenAlex.
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- Comparative Genomic Analysis of 450 Strains ofGenes · 2020Article
- Comparative Genomic Analysis of Virulence, Antimicrobial Resistance, and Plasmid Profiles ofMicrobial drug resistance (Larchmont, N.Y.) · 2019Article
- Geography Shapes the Population Genomics of Salmonella enterica Dublin.Genome biology and evolution · 2019Article
- Exploratory cohort study to determine if dry cow vaccination with a Salmonella Newport bacterin can protect dairy calves against oral Salmonella challenge.Journal of veterinary internal medicine · 2019Article
- Whole-Genome Sequences of Two Salmonella enterica Serovar Dublin Strains That Harbor theMicrobiology resource announcements · 2019Article
- Embracing Diversity: Differences in Virulence Mechanisms, Disease Severity, and Host Adaptations Contribute to the Success of NontyphoidalFrontiers in microbiology · 2019Review
- Bimodal Expression of theGenetics · 2018Article
- Genome-Wide Comparative Functional Analyses Reveal Adaptations ofFrontiers in microbiology · 2018Article
- The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence.The Journal of biological chemistry · 2016Article
- Whole genome sequencing provides insights into the genetic determinants of invasiveness in Salmonella Dublin.Epidemiology and infection · 2016Article
- Fast and efficient three-step target-specific curing of a virulence plasmid in Salmonella enterica.AMB Express · 2015Article
- Bacterial programming of host responses: coordination between type I interferon and cell death.Frontiers in microbiology · 2014Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The pathogenic role of the spv (Salmonella plasmid virulence) genes of Salmonella dublin was determined in the natural, bovine host. Since the lack of overt signs of enteritis or enterocolitis due to Salmonella infections in mice has limited the development of a convenient experimental system to study enteric disease, we used calves to study the contribution of the spv genes to S. dublin-induced salmonellosis. Since the SpvR transcriptional regulator is required for expression of the spvABCD operon, we constructed an spvR knockout mutation in a calf-virulent strain of S. dublin. Calves were infected with the wild-type strain, an spvR mutant, and an spvR mutant containing a complementing plasmid. Calves that were infected with the wild type or the complemented spvR mutant rapidly developed severe diarrhea and became moribund. Calves that were infected with the spvR mutant showed little or no clinical signs of systemic salmonellosis and developed only mild diarrhea. The survival and growth of the wild-type strain and the spvR mutant were determined by using blood-derived bovine monocytes. Wild-type S. dublin survived and grew inside cells, while the spvR mutant did not proliferate. These results suggest that the spv genes of S. dublin promote enhanced intracellular proliferation in intestinal tissues and at extraintestinal sites in the natural host.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.