ArticleProceedings of the National Academy of Sciences of the United States of America1997
A novel seizure-induced synaptotagmin gene identified by differential display.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 77 citations in OpenAlex.
- A comparative analysis of serum biochemistry, gene expression, and gut microbiota in domestication-susceptible and domestication-resistant mandarin fish (Siniperca chuatsi).Fish physiology and biochemistry · 2026Article
- Human mood disorder risk gene Synaptotagmin-14 contributes to mania-like behaviors in mice.Molecular psychiatry · 2025Article
- Phosphoproteome Analysis Identifies a Synaptotagmin-1-Associated Complex Involved in Ischemic Neuron Injury.Molecular & cellular proteomics : MCP · 2022Article
- Copy number variation analysis in 83 children with early-onset developmental and epileptic encephalopathy after targeted resequencing of a 109-epilepsy gene panel.Journal of human genetics · 2019Article
- Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Up-regulation of Synaptotagmin IV within amyloid plaque-associated dystrophic neurons in Tg2576 mouse model of Alzheimer's disease.Croatian medical journal · 2013Article
- Insights into food preference in hybrid F1 of Siniperca chuatsi (♀) × Siniperca scherzeri (♂) mandarin fish through transcriptome analysis.BMC genomics · 2013Article
- Amphiphysin I but not dynamin I nor synaptojanin mRNA expression increased after repeated methamphetamine administration in the rat cerebrum and cerebellum.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
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- Axonal and dendritic synaptotagmin isoforms revealed by a pHluorin-syt functional screen.Molecular biology of the cell · 2012Article
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- Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion.The Journal of biological chemistry · 2010Article
- Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms.The Journal of biological chemistry · 2008Article
- Synaptotagmin gene content of the sequenced genomes.BMC genomics · 2004Article
- The loss of circadian PAR bZip transcription factors results in epilepsy.Genes & development · 2004Article
- Past-A, a novel proton-associated sugar transporter, regulates glucose homeostasis in the brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- The AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosis.The Journal of cell biology · 2001Article
- Deficits in memory and motor performance in synaptotagmin IV mutant mice.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Screening of novel epilepsy-related genes and isolation and identification of cDNAs.Journal of Tongji Medical University = Tong ji yi ke da xue xue bao · 2000Article
- The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium.The EMBO journal · 1997Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic administration of kainic acid, a cyclic analogue of glutamate, produces many of the clinical features of human temporal lobe epilepsy and status epilepticus in rats, including the induction of motor convulsions and the degeneration of neurons in the hippocampus and piriform cortex. Differential display PCR was used to identify mRNAs that are differentially expressed between degenerating and nondegenerating tissues in the brain after kainic acid-induced seizure activity. A novel cDNA fragment expressed in the degenerating hippocampus and piriform cortex, but not in the nondegenerating parietal cortex, was identified, cloned, and sequenced. This novel cDNA fragment identified a new member of the synaptotagmin gene family that is rapidly and transiently induced in response to seizure activity. Differential expression of this synaptotagmin gene, syt X, was confirmed by Northern blot analysis and in situ hybridization. This novel, inducible synaptotagmin gene may provide a direct link between seizure-induced neuronal gene expression and subsequent modulation of synaptic structure and function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.