ArticleProceedings of the National Academy of Sciences of the United States of America1997
Importance of acidic, proline/serine/threonine-rich, and GTP-binding regions in the major histocompatibility complex class II transactivator: generation of transdominant-negative mutants.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 100 citations in OpenAlex.
- An Insight into the Role of GLIS1 in Embryonic Development, iPSC Generation, and Cancer.Advances in experimental medicine and biology · 2024Review
- The C-terminal transactivation domain of MITF interacts promiscuously with co-activator CBP/p300.Scientific reports · 2023Article
- Structural aspects of the MHC expression control system.Biophysical chemistry · 2022Review
- Cryopreservation process alters the expression of genes involved in pathways associated with the fertility of bull spermatozoa.Frontiers in genetics · 2022Article
- Article
- Revisiting the specificity of the MHC class II transactivator CIITA in classical murine dendritic cells in vivo.European journal of immunology · 2017Article
- Comparison of immunological characteristics of mesenchymal stem cells derived from human embryonic stem cells and bone marrow.Tissue engineering. Part A · 2015Article
- Molecular characterization of chicken class II transactivator gene.Immunogenetics · 2015Article
- CIITA and Its Dual Roles in MHC Gene Transcription.Frontiers in immunology · 2013Article
- Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins.The Journal of biological chemistry · 2012Article
- NLR family member NLRC5 is a transcriptional regulator of MHC class I genes.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Article
- Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator.The Journal of biological chemistry · 2008Article
- Novel mechanisms of class II major histocompatibility complex gene regulation.Immunologic research · 2003Review
- Phosphorylation of CIITA directs its oligomerization, accumulation and increased activity on MHCII promoters.The EMBO journal · 2002Article
- Function and regulation of class II transactivator in the immune system.Immunologic research · 2002Review
- The NOD: a signaling module that regulates apoptosis and host defense against pathogens.Oncogene · 2001Review
- A 36-amino-acid region of CIITA is an effective inhibitor of CBP: novel mechanism of gamma interferon-mediated suppression of collagen alpha(2)(I) and other promoters.Molecular and cellular biology · 2001Article
- Self-association of CIITA and its transactivation potential.Molecular and cellular biology · 2001Article
- Downregulation of CIITA function by protein kinase a (PKA)-mediated phosphorylation: mechanism of prostaglandin E, cyclic AMP, and PKA inhibition of class II major histocompatibility complex expression in monocytic lines.Molecular and cellular biology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The class II transactivator (CIITA) is a master transcription regulator of gene products involved in the exogenous antigen presentation pathway, including major histocompatibility complex (MHC) class II, invariant chain, and DM. An extensive analysis of the putative functional domains of CIITA is undertaken here to explore the action of CIITA. Antibodies to CIITA protein were produced to verify that these mutant proteins are expressed. Both acidic and proline/serine/threonine-rich domains are essential for class II MHC promoter activation. In addition, three guanine nucleotide-binding motifs are essential for CIITA activity. Of these mutants, two exhibited strong transdominant-negative functions. These two mutants provide a plausible approach to manipulate MHC class II expression and immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.