ArticleProceedings of the National Academy of Sciences of the United States of America1997
Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- The JAK1/STAT3/SOCS3 axis in bone development, physiology, and pathology.Experimental & molecular medicine · 2020Review
- Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome.The Journal of experimental medicine · 2020Article
- Targeting STAT-3 signaling pathway in cancer for development of novel drugs: Advancements and challenges.Genetics and molecular biology · 2020Article
- Activated gp130 signaling selectively targets B cell differentiation to induce mature lymphoma and plasmacytoma.JCI insight · 2019Article
- Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-Dependent and CD4Frontiers in immunology · 2018Article
- Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment.Immunity · 2011Article
- A role for IL-27p28 as an antagonist of gp130-mediated signaling.Nature immunology · 2010Article
- gp130 at the nexus of inflammation, autoimmunity, and cancer.Journal of leukocyte biology · 2010Review
- The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.The Journal of experimental medicine · 2009Article
- Article
- Silencing of B cell receptor signals in human naive B cells.The Journal of experimental medicine · 2002Article
- Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation.The Journal of experimental medicine · 2001Article
- IL-6-like cytokines and cancer cachexia: consequences of chronic inflammation.Immunologic research · 2001Review
- Review
- Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component.The Journal of experimental medicine · 1998Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
gp130 is a common signal-transducing receptor component for the interleukin 6 family of cytokines functioning in, for example, immune, hematopoietic, and nervous systems. In this study, to investigate the physiological functions of gp130 and to determine the pathological consequences of impaired gp130 signals, we have generated transgenic mice expressing a cytoplasmically truncated form of mouse gp130. Expression of this form of gp130 in lymphocytes significantly suppressed interleukin 6-induced tyrosine phosphorylation of endogenous gp130 and a downstream signaling molecule, signal transducer and activator of transcription 3, indicating that this form has a dominant negative function. In spite of the impaired gp130 signals, the development of lymphocytes in the transgenic mice appeared normal in terms of surface marker phenotypes. These mice, however, exhibited severe defects in antigen-specific antibody production of most immunoglobulin isotypes other than IgM after immunization with 2,4-dinitrophenol-conjugated ovalbumin. These results demonstrate in vivo that gp130 is essential for antigen-specific antibody production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.