ArticleProceedings of the National Academy of Sciences of the United States of America1997
Squid Pax-6 and eye development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Pax6 homologs are required for patterning both visual systems of the daddy-longlegs Phalangium opilio.Molecular biology and evolution · 2026Article
- Modulating the levels and activity of the retinal determination network is sufficient to induce the specification of distinct tissue fates in Drosophila.Development (Cambridge, England) · 2025Article
- Convergent expansions of keystone gene families drive metabolic innovation in Saccharomycotina yeasts.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Embryonic development of a centralised brain in coleoid cephalopods.Neural development · 2024Review
- Unfolding the ventral nerve center of chaetognaths.Neural development · 2024Article
- Emergence of novel genomic regulatory regions associated with light-organ development in the bobtail squid.iScience · 2023Article
- Article
- Semper's cells in the insect compound eye: Insights into ocular form and function.Developmental biology · 2021Review
- TheDevelopment (Cambridge, England) · 2020Article
- Article
- The Cephalopod Large Brain Enigma: Are Conserved Mechanisms of Stem Cell Expansion the Key?Frontiers in physiology · 2018Article
- Cephalopod Brains: An Overview of Current Knowledge to Facilitate Comparison With Vertebrates.Frontiers in physiology · 2018Review
- Article
- Scallop genome provides insights into evolution of bilaterian karyotype and development.Nature ecology & evolution · 2017Article
- Ancestral and novel roles of Pax family genes in mollusks.BMC evolutionary biology · 2017Article
- Eye Development inFrontiers in physiology · 2017Article
- The Pax gene family: Highlights from cephalopods.PloS one · 2017Article
- Pax6 in Collembola: Adaptive Evolution of Eye Regression.Scientific reports · 2016Article
- Cloning and Functional Analysis of Pax6 from the Hydrothermal Vent Tubeworm Ridgeia piscesae.PloS one · 2016Article
- Molecular Evidence for Convergence and Parallelism in Evolution of Complex Brains of Cephalopod Molluscs: Insights from Visual Systems.Integrative and comparative biology · 2015Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Pax-6 in vertebrates and its homolog eyeless in Drosophila are known to be essential for eye development. Here we investigate the role of Pax-6 in eye development in another major systematic group, molluscs. We demonstrate that alternatively spliced RNAs derived from a single Pax-6 gene in the squid (Loligo opalescens) are expressed in the embryonic eye, olfactory organ, brain, and arms. Despite significant sequence differences between squid Pax-6 and Drosophila eyeless in the region outside the paired- and homeodomains, squid Pax-6 is able to induce the formation of ectopic eyes in Drosophila. Our results support the idea that Pax-6 related genes are necessary for eye and olfactory system formation throughout the animal kingdom.
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