ArticleProceedings of the National Academy of Sciences of the United States of America1997
Function and regulation of heat shock factor 2 during mouse embryogenesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 137 citations in OpenAlex.
- HSF2 drives breast cancer progression by acting as a stage-specific switch between proliferation and invasion.Science advances · 2025Article
- A guide to heat shock factors as multifunctional transcriptional regulators.The FEBS journal · 2025Review
- CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder.Nature communications · 2022Article
- Heat Shock Transcription Factor 2 Is Significantly Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel Mechanisms of Several Severe Diseases.International journal of molecular sciences · 2022Review
- Article
- The proteostasis guardian HSF1 directs the transcription of its paralog and interactor HSF2 during proteasome dysfunction.Cellular and molecular life sciences : CMLS · 2021Article
- Pan-Cancer Integrated Analysis of HSF2 Expression, Prognostic Value and Potential Implications for Cancer Immunity.Frontiers in molecular biosciences · 2021Article
- Integrated Bioinformatics Analysis Identifies Heat Shock Factor 2 as a Prognostic Biomarker Associated With Immune Cell Infiltration in Hepatocellular Carcinoma.Frontiers in genetics · 2021Article
- Tailoring of Proteostasis Networks with Heat Shock Factors.Cold Spring Harbor perspectives in biology · 2019Review
- Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival.The Journal of cell biology · 2014Article
- Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndrome.EMBO molecular medicine · 2014Article
- Novel isoforms of heat shock transcription factor 1, HSF1γα and HSF1γβ, regulate chaperone protein gene transcription.The Journal of biological chemistry · 2014Article
- Impact of exercise and metabolic disorders on heat shock proteins and vascular inflammation.Autoimmune diseases · 2012Article
- Role of heat shock proteins in stem cell behavior.Progress in molecular biology and translational science · 2012Review
- Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress.Molecular and cellular biology · 2010Article
- Analysis of chaperone mRNA expression in the adult mouse brain by meta analysis of the Allen Brain Atlas.PloS one · 2010Article
- Heat shock factors: integrators of cell stress, development and lifespan.Nature reviews. Molecular cell biology · 2010Review
- NeuroD6 genomic signature bridging neuronal differentiation to survival via the molecular chaperone network.Journal of neuroscience research · 2010Article
- Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli.Molecular biology of the cell · 2009Article
- Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spontaneous expression of heat shock genes during development is well documented in many animal species, but the mechanisms responsible for this developmental regulation are only poorly understood. In vertebrates, additional heat shock transcription factors, distinct from the heat shock factor 1 (HSF1) involved in the stress response, were suggested to be involved in this developmental control. In particular, the mouse HSF2 has been found to be active in testis and during preimplantation development. However, the role of HSF2 and its mechanism of activation have remained elusive due to the paucity of data on its expression during development. In this study, we have examined HSF2 expression during the postimplantation phase of mouse development. Our data show a developmental regulation of HSF2, which is expressed at least until 15.5 days of embryogenesis. It becomes restricted to the central nervous system during the second half of gestation. It is expressed in the ventricular layer of the neural tube which contains mitotically active cells but not in postmitotic neurons. Parallel results were obtained for mRNA, protein, and activity levels, demonstrating that the main level of control was transcriptional. The detailed analysis of the activity of a luciferase reporter gene under the control of the hsp70.1 promoter, as well as the description of the protein expression patterns of the major heat shock proteins in the central nervous system, show that HSF2 and heat shock protein expression domains do not coincide. This result suggests that HFS2 might be involved in other regulatory developmental pathways and paves the way to new functional approaches.
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