ArticleProceedings of the National Academy of Sciences of the United States of America1997
Supercoil-induced extrusion of a regulatory DNA hairpin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 83 citations in OpenAlex.
- Cryo-EM study of bacteriophage N4 virion RNA polymerase.Journal of bacteriology · 2026Article
- Article
- Cruciform Formable Sequences withinInternational journal of molecular sciences · 2021Article
- MD-TSPC4: Computational Method for Predicting the Thermal Stability of I-Motif.International journal of molecular sciences · 2020Article
- A strong structural correlation between short inverted repeat sequences and the polyadenylation signal in yeast and nucleosome exclusion by these inverted repeats.Current genetics · 2019Article
- Requirement or exclusion of inverted repeat sequences with cruciform-forming potential in Escherichia coli revealed by genome-wide analyses.Current genetics · 2018Article
- Telomere associated primase Tap repairs truncated telomeres of Streptomyces.Nucleic acids research · 2017Article
- DNA-DNA kissing complexes as a new tool for the assembly of DNA nanostructures.Nucleic acids research · 2016Article
- Structural diversity of supercoiled DNA.Nature communications · 2015Article
- Structural and biochemical investigation of bacteriophage N4-encoded RNA polymerases.Biomolecules · 2015Review
- Potential non-B DNA regions in the human genome are associated with higher rates of nucleotide mutation and expression variation.Nucleic acids research · 2014Article
- DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures.Nucleic acids research · 2014Article
- Probing mercury(II)-DNA interactions by nanopore stochastic sensing.The journal of physical chemistry. B · 2013Article
- Target site recognition by a diversity-generating retroelement.PLoS genetics · 2011Article
- Self-catalyzed site-specific depurination of G residues mediated by cruciform extrusion in closed circular DNA plasmids.The Journal of biological chemistry · 2011Article
- Identification and characterization of two critical sequences in SV40PolyA that activate the green fluorescent protein reporter gene.Genetics and molecular biology · 2011Article
- Real-time detection of cruciform extrusion by single-molecule DNA nanomanipulation.Nucleic acids research · 2011Article
- Folded DNA in action: hairpin formation and biological functions in prokaryotes.Microbiology and molecular biology reviews : MMBR · 2010Review
- The distribution of inverted repeat sequences in the Saccharomyces cerevisiae genome.Current genetics · 2010Article
- Streptomyces telomeres contain a promoter.Journal of bacteriology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Bacteriophage N4 virion RNA polymerase (N4 vRNAP) promoters contain inverted repeats, which form a 5- to 7-base-pair stem, 3-base loop hairpin that is required for vRNAP recognition. We show that, contrary to certain theoretical predictions, hairpin extrusion can occur at physiological superhelical densities in a Mg2+-dependent manner. Specific sequences on the template strand are required for hairpin extrusion. These sequences define stable DNA hairpins that are relatively unreactive to single strand-specific probes. In addition, a specific stable hairpin-inducing sequence can regulate transcription in vivo. Thus, a DNA structure, in its natural environment, is involved in transcriptional regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.