ArticleMolecular and cellular biology1997
The adenovirus E1A repression domain disrupts the interaction between the TATA binding protein and the TATA box in a manner reversible by TFIIB.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Article
- The adenovirus E1A N-terminal repression domain represses transcription from a chromatin template in vitro.Virology · 2012Article
- Article
- Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP.Nucleic acids research · 2009Article
- The transcription-repression domain of the adenovirus E1A oncoprotein targets p300 at the promoter.Oncogene · 2008Article
- Adenovirus E1A proteins are closely associated with chromatin in productively infected and transformed cells.Virology · 2008Article
- Vaccinia virus intermediate and late promoter elements are targeted by the TATA-binding protein.Journal of virology · 2006Article
- Recruitment of CBP/p300, TATA-binding protein, and S8 to distinct regions at the N terminus of adenovirus E1A.Journal of virology · 2005Article
- Transgenic expression in mouse lung reveals distinct biological roles for the adenovirus type 5 E1A 243- and 289-amino-acid proteins.Journal of virology · 2002Article
- Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2.The Journal of biological chemistry · 2002Article
- Adenovirus E1A N-terminal amino acid sequence requirements for repression of transcription in vitro and in vivo correlate with those required for E1A interference with TBP-TATA complex formation.Journal of virology · 2002Article
- Even-skipped represses transcription by binding TATA binding protein and blocking the TFIID-TATA box interaction.Molecular and cellular biology · 1998Article
- p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene.Molecular and cellular biology · 1998Article
- Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
The human adenovirus E1A 243 amino acid oncoprotein possesses a transcription repression function that appears to be linked with its ability to induce cell cycle progression and to inhibit cell differentiation. The molecular mechanism of E1A repression has been poorly understood. Recently, we reported that the TATA binding protein (TBP) is a cellular target of E1A repression. Here we demonstrate that the interaction between TBP and the E1A repression domain is direct and specific. The TBP binding domain within E1A 243R maps to E1A N-terminal residues approximately 1 to 35 and is distinct from the TBP binding domain within conserved region 3 unique to the E1A 289R transactivator. An E1A protein fragment consisting of only the E1A N-terminal 80 amino acids (E1A 1-80) and containing the E1A repression function was found to block the interaction between TBP and the TATA box element as shown by gel mobility and DNase protection analysis. Interestingly, a preformed TBP-TATA box promoter complex can be dissociated by E1A 1-80. Further, TFIIB can prevent E1A disruption of TBP-TATA box interaction. TFIIB, like TBP, can overcome E1A repression of transcription in vitro. The ability of the E1A repression domain to block TBP interaction with the TATA box and the ability of TFIIB to reverse E1A disruption of the TBP-TATA box complex implies a mechanism for E1A repression distinct from those of known cellular repressors that target TBP.
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