ArticleMolecular and cellular biology1997
The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Transcription factor E4F1 as a regulator of cell life and disease progression.Science advances · 2023Review
- E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell Proliferation and Fertility in Mice.Animals : an open access journal from MDPI · 2020Article
- Article
- Review
- Modulation of Tcf3 repressor complex composition regulates cdx4 expression in zebrafish.The EMBO journal · 2011Article
- Article
- The role of LANP and ataxin 1 in E4F-mediated transcriptional repression.EMBO reports · 2007Article
- The LIM-only protein FHL2 is a negative regulator of E4F1.Oncogene · 2006Article
- The E4F protein is required for mitotic progression during embryonic cell cycles.Molecular and cellular biology · 2004Article
- Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2.Molecular and cellular biology · 2003Article
- Article
- Review
- Cyclin A is a mediator of p120E4F-dependent cell cycle arrest in G1.Molecular and cellular biology · 2001Article
- pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- p53 is involved in the p120E4F-mediated growth arrest.Oncogene · 2000Article
- Suppression of E1A-mediated transformation by the p50E4F transcription factor.Molecular and cellular biology · 1999Article
- AR1 is an integral part of the adenovirus type 2 E1A-CR3 transactivation domain.Journal of virology · 1998Article
- Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- Adenovirus E1A-regulated transcription factor p120E4F inhibits cell growth and induces the stabilization of the cdk inhibitor p21WAF1.Molecular and cellular biology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A 50-kDa cellular factor, E4F, has been implicated in mediating trans activation of the adenovirus E4 gene by the 289R E1A(13S) protein. Previous experiments demonstrated an E1A-dependent increase in E4F DNA binding activity, dependent on phosphorylation, that correlated with the activation of E4 transcription. Using expression screening, we isolated a cDNA clone encoding the E4F protein, as judged by DNA binding characteristics, transcriptional activation, and immunological criteria. The E4F-1 cDNA encodes a 783-amino-acid polypeptide that has 86% sequence identity with the murine nuclear factor phiAP3, a GLI-krüppel-related protein. E4F DNA binding activity is encoded within an amino-terminal region of E4F-1 that contains a zinc finger domain and, as with endogenous E4F, is phosphatase sensitive. We found that E4F was generated from the full-length E4F-1-encoded protein as a 50-kDa amino-terminal fragment. Moreover, E1A(13S) expression induced the phosphorylation of both forms of E4F-1 but differentially regulated their DNA binding activities, stimulating the 50-kDa fragment while reducing the activity of the full-length protein. In transient-transfection assays, the E4F-1 amino-terminal fragment stimulated the adenovirus E4 promoter in the presence of E1A(13S), whereas the full-length protein repressed the promoter in the absence, but not the presence, of E1A. The results indicate that the 50-kDa polypeptide responsible for E4F DNA binding activity is a fragment generated from the human homolog of phiAP3 and that the two forms of the E4F-1 protein are differentially regulated by E1A through phosphorylation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.