ArticleMolecular and cellular biology1997
Interaction of a Swi3 homolog with Sth1 provides evidence for a Swi/Snf-related complex with an essential function in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Application of the 3C Method to Study the Developmental Genes inFrontiers in genetics · 2022Article
- Structure of the RSC complex bound to the nucleosome.Science (New York, N.Y.) · 2019Article
- Contrasting roles of the RSC and ISW1/CHD1 chromatin remodelers in RNA polymerase II elongation and termination.Genome research · 2019Article
- The LSH/HELLS homolog Irc5 contributes to cohesin association with chromatin in yeast.Nucleic acids research · 2017Article
- RSC-dependent constructive and destructive interference between opposing arrays of phased nucleosomes in yeast.Genome research · 2014Article
- Cytoplasmic interaction of the tumour suppressor protein hSNF5 with dynamin-2 controls endocytosis.Oncogene · 2014Article
- Involvement of a Toxoplasma gondii chromatin remodeling complex ortholog in developmental regulation.PloS one · 2011Article
- Improved methods for expression and purification of Saccharomyces cerevisiae TFIIF and TFIIH; identification of a functional Escherichia coli promoter and internal translation initiation within the N-terminal coding region of the TFIIF TFG1 subunit.Protein expression and purification · 2010Article
- Functions of Saccharomyces cerevisiae TFIIF during transcription start site utilization.Molecular and cellular biology · 2008Article
- Unique, shared, and redundant roles for the Arabidopsis SWI/SNF chromatin remodeling ATPases BRAHMA and SPLAYED.The Plant cell · 2007Article
- The putative SWI/SNF complex subunit BRAHMA activates flower homeotic genes in Arabidopsis thaliana.Plant molecular biology · 2006Article
- Genetic interactions between TFIIF and TFIIS.Genetics · 2006Article
- Molecular genetic analysis of an SNF2/brahma-related gene in Tetrahymena thermophila suggests roles in growth and nuclear development.Eukaryotic cell · 2006Article
- Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles.Genetics · 2006Article
- The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation.Molecular and cellular biology · 2003Article
- Chromatin remodeling by RSC involves ATP-dependent DNA translocation.Genes & development · 2002Article
- The SWIRM domain: a conserved module found in chromosomal proteins points to novel chromatin-modifying activities.Genome biology · 2002Article
- RSC2, encoding a component of the RSC nucleosome remodeling complex, is essential for 2 microm plasmid maintenance in Saccharomyces cerevisiae.Molecular and cellular biology · 2002Article
- Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex.Genes & development · 2002Article
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
The Saccharomyces cerevisiae Swi/Snf complex has a role in remodeling chromatin structure to facilitate transcriptional activation. The complex has 11 components, including Swi1/Adr6, Swi2/Snf2, Swi3, Snf5, Snf6, Snf11, Swp73/Snf12, and Tfg3. Mammalian homologs of these proteins have been shown to form multiple Swi/Snf-related complexes. Here we characterize an S. cerevisiae Swi3 homolog (Swh3) and present evidence that it associates in a complex with a Snf2 homolog, Sthl. We identified Swh3 as a protein that interacts with the N terminus of Snf2 in the two-hybrid system. Swh3 and Swi3 are functionally distinct, and overexpression of one does not compensate for loss of the other. Swh3 is essential for viability and does not activate transcription of reporters. The Snf2 sequence that interacts with Swh3 was mapped to a region conserved in Sth1. We show that Swh3 and Sth1 fusion proteins interact in the two-hybrid system and coimmunoprecipitate from yeast cell extracts. We also map interactions between Swh3 and Sth1 and examine the role of a leucine zipper motif in self-association of Swh3. These findings, together with previous analysis of Sth1, indicate that Swh3 and Sth1 are associated in a complex that is functionally distinct from the Swi/Snf complex and essential for viability.
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