ArticleJournal of neuro-oncology1997
Inhibitory effects of CAI in glioblastoma growth and invasion.
Article in Journal of neuro-oncology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Phase II clinical and pharmacologic study of radiation therapy and carboxyamido-triazole (CAI) in adults with newly diagnosed glioblastoma multiforme.Investigational new drugs · 2007Trial
- Development of Store-Operated Calcium Entry-Targeted Compounds in Cancer.Frontiers in pharmacology · 2021Review
- Multicenter Phase IB Trial of Carboxyamidotriazole Orotate and Temozolomide for Recurrent and Newly Diagnosed Glioblastoma and Other Anaplastic Gliomas.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Article
- TNF receptor-associated factor 6 regulates proliferation, apoptosis, and invasion of glioma cells.Molecular and cellular biochemistry · 2013Article
- Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-κB activation.Molecular biology of the cell · 2012Article
- Targeting retinal and choroid neovascularization using the small molecule inhibitor carboxyamidotriazole.Brain research bulletin · 2010Article
- The invasiveness of five medulloblastoma cell lines in collagen gels.Journal of neuro-oncology · 2010Article
- Involvement of Hif-1 in desferrioxamine-induced invasion of glioblastoma cells.Clinical & experimental metastasis · 2007Article
- Interferon-inducible protein 9 (CXCL11)-induced cell motility in keratinocytes requires calcium flux-dependent activation of mu-calpain.Molecular and cellular biology · 2005Article
- Non-cytotoxic therapies for malignant gliomas.Journal of neuro-oncology · 2002Review
- Inhibition of angiogenesis: treatment options for patients with metastatic prostate cancer.Investigational new drugs · 2002Review
- Article
- Multi-agent cytostatic treatment of 'low-grade' gliomas.Current oncology reports · 2000Review
- Angiogenesis inhibitors.Current oncology reports · 2000Review
- "...those left behind." Biology and oncology of invasive glioma cells.Neoplasia (New York, N.Y.) · 1999Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While distant metastases are rare in patients with primary brain malignancies, local growth and invasion are common and life-threatening. Regional infiltration is responsible for the failure of local therapies, resulting in tumor recurrence, progression, and death. The process of invasion requires cellular adhesion, local proteolysis and migration. CAI, carboxyamide-triazole, is an anticancer agent developed as an inhibitor of selected signal transduction pathways. Studies on the effects of CAI on human glioblastoma growth and invasiveness are presented. CAI inhibited proliferation of 6 of 8 cell lines tested in a dose-dependent fashion in vitro (IC50 range 1.5-44 microM), with no effect on the U373 line. Inhibition of adhesion to tissue culture plastic was observed for the H4, T98G, and U373 lines pretreated with CAI; H4 and T98G were inhibited in adhesion to collagen type IV. Incubation with CAI decreased production of the 72 kDa and 92 kDa type IV collagenases in all cell lines, ranging from 16 to 93% inhibition. These observations show that the effects of CAI on cell line behavior can vary between lines that are similar in origin. Despite variability in the inhibitory effects for proliferation and adhesion, CAI is consistently able to inhibit the invasive phenotype of all glioma cell lines in vitro using the Matrigel barrier assay (IC50 range 13-28 microM). These observations suggest that CAI may have benefit in the treatment of gliomas and high grade astrocytomas.
Indexed as
Identifiers
9120549What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.