ArticleThe Journal of clinical investigation1997
A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00857844 (Genetic Predisposition of Chronic Nephrotoxicity From Calcineurin Inhibitors in Liver Transplant Recipients, Potential Correlation With Urinary Biomarkers), which is not on this map. Cited by 126 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Predisposition of Chronic Nephrotoxicity From Calcineurin Inhibitors in Liver Transplant Recipients, Potential Correlation With Urinary Biomarkers
Who cites it
126 citing papers in PubMed, 1 synthesis or guideline pooled it, 549 citations in OpenAlex.
- A-6G and A-20C polymorphisms in the angiotensinogen promoter and hypertension risk in Chinese: a meta-analysis.PloS one · 2011Pooled it
- Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study.Journal of hypertension · 2008Trial
- A1166C variant of angiotensin II type 1 receptor gene is associated with severe hypertension in pregnancy independently of T235 variant of angiotensinogen gene.Journal of human genetics · 2004Trial
- Importance of selected genetic determinants on endurance performance and physical strength: a narrative review.Frontiers in physiology · 2025Review
- Analysis of the combined effect of rs699 and rs5051 on angiotensinogen expression and hypertension.Chronic diseases and translational medicine · 2024Article
- Sex differences in fetal kidney reprogramming: the case in the renin-angiotensin system.Pediatric nephrology (Berlin, Germany) · 2024Review
- Blood Levels of Angiotensinogen and Hypertension in the Multi-Ethnic Study of Atherosclerosis (MESA).Journal of the American College of Cardiology · 2023Article
- The alleles of AGT and HIF1A gene affect the risk of hypertension in plateau residents.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Genetic Factors of Renin-Angiotensin System Associated with Major Bleeding for Patients Treated with Direct Oral Anticoagulants.Pharmaceutics · 2022Article
- Mapping the miRNA-mRNA Interactome in Human Hepatocytes and Identification of Functional mirSNPs in Pharmacogenes.Clinical pharmacology and therapeutics · 2021Article
- Population genetics: past, present, and future.Human genetics · 2021Review
- Association BetweenFrontiers in cardiovascular medicine · 2021Article
- Angiotensinogen and the Modulation of Blood Pressure.Frontiers in cardiovascular medicine · 2021Review
- Regulators of Epithelial Sodium Channels in Aldosterone-Sensitive Distal Nephrons (ASDN): Critical Roles of Nedd4L/Nedd4-2 and Salt-Sensitive Hypertension.International journal of molecular sciences · 2020Review
- An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease.Disease markers · 2019Article
- Contribution of Four Polymorphisms in Renin-Angiotensin-Aldosterone-Related Genes to Hypertension in a Thai Population.International journal of hypertension · 2019Article
- Angiotensinogen rs5050 germline genetic variant as potential biomarker of poor prognosis in astrocytoma.PloS one · 2018Article
- Renin-angiotensin system gene polymorphisms and high blood pressure in Lithuanian children and adolescents.BMC medical genetics · 2017Article
- Simultaneous Genotyping of the rs4762 and rs699 Polymorphisms in Angiotensinogen Gene and Correlation with Iranian CAD Patients with Novel Hexa-primer ARMS-PCR.Iranian journal of public health · 2017Article
- Essential hypertension: A filtered serum based metabolomics study.Scientific reports · 2017Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 4 countries.
Funding
Abstract
In earlier studies, we provided statistical evidence that individual differences in the angiotensinogen gene, the precursor of the vasoactive hormone angiotensin II, constitute inherited predispositions to essential hypertension in humans. We have now identified a common variant in the proximal promoter, the presence of an adenine, instead of a guanine, 6 bp upstream from the initiation site of transcription, in significant association with the disorder. Tests of promoter activity and DNA binding studies with nuclear proteins suggest that this nucleotide substitution affects the basal transcription rate of the gene. These observations provide some biological insight about the possible mechanism of a genetic predisposition to essential hypertension; they may also have important evolutionary implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.