ArticleThe Journal of clinical investigation1997
In utero exposure to helminth and mycobacterial antigens generates cytokine responses similar to that observed in adults.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 160 citations in OpenAlex.
- Effect of maternal praziquantel treatment for Schistosoma japonicum infection on the offspring susceptibility and immunologic response to infection at age six, a cohort study.PLoS neglected tropical diseases · 2021Trial
- Placental gene expression and antibody levels of mother-neonate pairs reveal an enhanced risk for inflammation in a helminth endemic country.Scientific reports · 2019Trial
- The effect of maternal helminth infection on maternal and neonatal immune function and immunity to tuberculosis.PloS one · 2014Trial
- Effect of maternal Schistosoma mansoni infection and praziquantel treatment during pregnancy on Schistosoma mansoni infection and immune responsiveness among offspring at age five years.PLoS neglected tropical diseases · 2013Trial
- Treatment with anthelminthics during pregnancy: what gains and what risks for the mother and child?Parasitology · 2011Trial
- Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial.BMC infectious diseases · 2011Trial
- Anthelminthic treatment during pregnancy is associated with increased risk of infantile eczema: randomised-controlled trial results.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2011Trial
- A longitudinal study of BCG vaccination in early childhood: the development of innate and adaptive immune responses.PloS one · 2010Trial
- Trial
- Dynamic changes in peripheral blood CD4+ T cell subsets are associated with litter performance in primiparous gestating sows.Journal of animal science · 2025Article
- Prenatal Maternal Immunization for Infant Protection: A Review of the Vaccines Recommended, Infant Immunity and Future Research Directions.Pathogens (Basel, Switzerland) · 2024Review
- Altered Offspring Immunity in Maternal Parasitic Infections.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- The Road to Elimination: Current State of Schistosomiasis Research and Progress Towards the End Game.Frontiers in immunology · 2022Review
- Immunological Considerations forFrontiers in immunology · 2021Review
- The Protective Role of Maternal Immunization in Early Life.Frontiers in pediatrics · 2021Review
- Age-Related Changes in Thymic Central Tolerance.Frontiers in immunology · 2021Review
- Impact of Helminth Infections during Pregnancy on Vaccine Immunogenicity in Gabonese Infants.Vaccines · 2020Article
- Mechanisms of Fetal T Cell Tolerance and Immune Regulation.Frontiers in immunology · 2020Review
- Maternal LatentFrontiers in immunology · 2020Observational
- Early Childhood Anemia in a Birth Cohort in Coastal Kenya: Links to Infection and Nutrition.The American journal of tropical medicine and hygiene · 2019Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonates exposed to parasite antigens (Ags) in utero may develop altered fetal immunity that could affect subsequent responses to infection. We hypothesized that cord blood lymphocytes (CBL) from offspring of mothers residing in an area highly endemic for schistosomiasis, filariasis, and tuberculosis in Kenya would either fail to respond or generate a predominantly Th2-associated cytokine response to helminth and mycobacterial antigens (PPD) in vitro compared to maternal PBMC. Kenyan CBL generated helminth Ag-specific IL-5 (range 29-194 pg/ml), IL-10 (121-2,115 pg/ml), and/or IFN-gamma (78 pg/ml-10.6 ng/ml) in 26, 46, and 57% of neonates, respectively (n = 40). PPD induced IFN-gamma in 30% of Kenyan CBL (range 79-1,896 pg/ml), but little or no IL-4 or IL-5. No Ag-specific IL-4, IL-5, or IFN-gamma release was detected by CBL obtained in the United States (n = 11). Ag-driven cytokine production was primarily CD4-dependent. Cytokine responses to helminth and mycobacterial Ags by maternal PBMC mirrored that observed in neonates. CBL from helminth infected and/or PPD-sensitized mothers produced more Ag-specific cytokines compared to CBL from uninfected mothers (P < 0.05). These data demonstrate that the human fetus develops similar patterns of cytokine production observed in adults and indicates that prenatal exposure may not lead to tolerance or altered fetal immunity. .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.