Trial reportClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology1997
Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo.
Trial report in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05775952 (Comparison of Airway Remodeling Mediators Following Experimental Human Rhinovirus Infection in Subjects With Mild to Moderate Asthma and Healthy, Non-asthmatic Control Subjects), which is not on this map. Cited by 62 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Airway Remodeling Mediators Following Experimental Human Rhinovirus Infection in Subjects With Mild to Moderate Asthma and Healthy, Non-asthmatic Control Subjects
Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 198 citations in OpenAlex.
- Rhinovirus-Induced Cytokine Alterations With Potential Implications in Asthma Exacerbations: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2022Pooled it
- Trial
- Association of asthma and bronchiectasis: Mendelian randomization analyses and observational study.Respiratory research · 2024Observational
- Infectious and Inflammatory Pathways to Cough.Annual review of physiology · 2023Review
- Strong and consistent associations of precedent chronic rhinosinusitis with risk of non-cystic fibrosis bronchiectasis.The Journal of allergy and clinical immunology · 2022Article
- Extracellular Vesicles from Airway Secretions: New Insights in Lung Diseases.International journal of molecular sciences · 2021Review
- The Expression of ephrinA1/ephA2 Receptor Increases in Chronic Rhinosinusitis and ephrinA1/ephA2 Signaling Affects Rhinovirus-Induced Innate Immunity in Human Sinonasal Epithelial Cells.Frontiers in immunology · 2021Article
- Rhinovirus C15 Induces Airway Hyperresponsiveness via Calcium Mobilization in Airway Smooth Muscle.American journal of respiratory cell and molecular biology · 2020Article
- Rhinovirus and Innate Immune Function of Airway Epithelium.Frontiers in cellular and infection microbiology · 2020Review
- NETopathic Inflammation in Chronic Obstructive Pulmonary Disease and Severe Asthma.Frontiers in immunology · 2019Review
- Modulation of airway hyperresponsiveness by rhinovirus exposure.Respiratory research · 2018Review
- Gene expression patterns induced at different stages of rhinovirus infection in human alveolar epithelial cells.PloS one · 2017Article
- Review
- How does rhinovirus cause the common cold cough?BMJ open respiratory research · 2016Article
- Changes in microbiota during experimental human Rhinovirus infection.BMC infectious diseases · 2015Article
- Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease.Pulmonary pharmacology & therapeutics · 2015Review
- Article
- Vitamin C and common cold-induced asthma: a systematic review and statistical analysis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2013Article
- Lower respiratory tract infection induced by a genetically modified picornavirus in its natural murine host.PloS one · 2012Article
- Lower airway rhinovirus burden and the seasonal risk of asthma exacerbation.American journal of respiratory and critical care medicine · 2011Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma exacerbations are closely associated with respiratory virus infections. However, the pathophysiological consequences of such infections in asthma are largely unclear.
objectiveTo examine the effect of rhinovirus 16 (RV16) infection on airway hypersensitivity to histamine, and on interleukin-8 (IL-8) in nasal lavage.
methodsTwenty-seven non-smoking atopic, mildly asthmatic subjects participated in a placebo-controlled, parallel study. A dose of 0.5-2.9 x 10(4) TCID50 RV16 or placebo was nasally administered. Cold symptoms were recorded by questionnaire throughout the study. Histamine challenges were performed at entry, and on days 4 and 11 after inoculation. Nasal lavages were obtained at entry, and on days 2 and 9. The response to histamine was measured by PC20 (changes expressed as doubling doses: DD) IL-8 levels were obtained by ELISA, and were expressed in ng/ml.
resultsRV infection was confirmed by culture of nasal lavage and/or by antibody titre rise in each of the RV16-treated subjects. Among the 19 RV 16-treated subjects, eight developed severe cold symptoms. Baseline FEV1, did not change significantly during the study in either treatment group (P = 0.99). However, in the RV16-treated subjects there was a decrease in PC20 at day 4, which was most pronounced in those with a severe cold (mean change +/- SEM: -1.14 +/- 0.28 DD, P = 0.01). In addition, IL-8 levels increased in the RV16 group at days 2 and 9 (P < 0.001). The increase in nasal IL-8 at day 2 correlated significantly with the change in PC20 at day 4 (r = -0.48, P = 0.04).
conclusionWe conclude that the severity of cold, as induced by experimental RV16 infection, is a determinant of the increase in airway hypersensitivity to histamine in patients with asthma. Our results suggest that this may be mediated by an inflammatory mechanism, involving the release of chemokines such as IL-8.
Indexed as
Identifiers
9117878PMC7164827W2171241162What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.