ArticleProceedings of the National Academy of Sciences of the United States of America1997
Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 103 citations in OpenAlex.
- PSAP Protects Against Acute Myocardial Ischemia-Reperfusion Injury by Promoting ASAH1-Mediated Ceramide Metabolism.Journal of cardiovascular translational research · 2026Article
- Significant expression of prosaposin in the intermediate lobe of mouse pituitary gland.Cell and tissue research · 2026Article
- Prosaposin orchestrates a TGFβ1-driven paracrine loop between Schwann cells and gastric cancer to accelerate perineural invasion.Journal of experimental & clinical cancer research : CR · 2026Article
- Integrating single-cell and spatial transcriptomics reveals the cellular heterogeneity of vestibular schwannoma.NPJ precision oncology · 2025Article
- Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1 mRNAs, in the chick inner ear.Cell and tissue research · 2023Article
- Expression of prosaposin and its G protein-coupled receptor (GPR) 37 in mouse cochlear and vestibular nuclei.The Journal of veterinary medical science · 2023Article
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- Hypoxia-ischemia alters distribution of lysosomal proteins in rat cortex and hippocampus.Biology open · 2018Article
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- The protective role of prosaposin and its receptors in the nervous system.Brain research · 2014Review
- GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Decrease in prosaposin in the Dystrophic mdx mouse brain.PloS one · 2013Article
- Integrin signaling in oligodendrocytes and its importance in CNS myelination.Journal of signal transduction · 2011Article
- The role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin.The Journal of cell biology · 2010Article
- JC virus agnoprotein inhibits in vitro differentiation of oligodendrocytes and promotes apoptosis.Journal of virology · 2008Article
- A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents.The Journal of clinical investigation · 2008Article
- Neurolysosomal pathology in human prosaposin deficiency suggests essential neurotrophic function of prosaposin.Acta neuropathologica · 2007Article
- The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: possible implications in peripheral nerve injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- The exon 8-containing prosaposin gene splice variant is dispensable for mouse development, lysosomal function, and secretion.Molecular and cellular biology · 2005Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Prosaposin, the precursor of saposins A, B, C, and D, was recently identified as a neurotrophic factor. Herein prosaposin was found to increase sulfatide concentrations in primary and transformed Schwann cells (iSC) and oligodendrocytes (differentiated CG4 cells). Of the four mature saposins, only saposin C was found to increase sulfatide concentrations in these cell types. A similar result was obtained by using peptides (prosaptides) encompassing the neurotrophic sequence located in the saposin C domain. Dose-response curves demonstrated maximal enhancement by saposin C and prosaptides at low nanomolar concentrations (5-10 nM). The increase in sulfatide concentration by a 14-mer prosaptide, TX14(A), in CG4 oligodendrocytes was about 3-fold greater than in primary Schwann cells. A mutant prosaptide with a single amino acid replacement of Asn --> Asp was inactive. Prosaptides did not induce cell proliferation of primary Schwann cells, iSC cells, or CG4 oligodendrocytes but nanomolar concentrations of prosaptides prevented cell death of iSC cells and CG4 oligodendrocytes. Immunoblot analysis demonstrated that phosphorylation of both mitogen-activated protein kinase p-42 and p-44 isoforms were enhanced 3- to 5-fold after 5 min of treatment with prosaptides at concentrations of 1-5 nM. These findings suggest that prosaposin and prosaptides bind to a receptor that initiates signal transduction to promote myelin lipid synthesis and prolong cell survival in both Schwann cells and oligodendrocytes. Prosaposin may function as a myelinotrophic factor in vivo during development and repair of myelinated nerves explaining the deficiency of myelin observed in prosaposin-deficient mice and humans.
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