ArticleProceedings of the National Academy of Sciences of the United States of America1997
The regulator of early gliogenesis glial cells missing is a transcription factor with a novel type of DNA-binding domain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 115 citations in OpenAlex.
- Written in the Stars: Astrocyte Biology From Evolution to Disease.Acta physiologica (Oxford, England) · 2026Review
- A Subset of Circulating Hemocytes Expresses Genes Indicating Neural Precursor Identity.Cellular and molecular neurobiology · 2026Article
- Autoregulation of the glial gene reversed polarity in Drosophila.Scientific reports · 2025Article
- CRISPR screening in human trophoblast stem cells reveals both shared and distinct aspects of human and mouse placental development.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Novel Glial Cells Missing-2 (GCM2) variants in parathyroid disorders.European journal of endocrinology · 2022Article
- Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington's disease mice.Nature communications · 2021Article
- GCM2-Activating Mutations in Familial Isolated Hyperparathyroidism.American journal of human genetics · 2016Article
- Functional Conservation of the Glide/Gcm Regulatory Network Controlling Glia, Hemocyte, and Tendon Cell Differentiation in Drosophila.Genetics · 2016Article
- Identification and characterization of C106R, a novel mutation in the DNA-binding domain of GCMB, in a family with autosomal-dominant hypoparathyroidism.Clinical endocrinology · 2012Article
- Mutational analysis of GCMB, a parathyroid-specific transcription factor, in parathyroid adenoma of primary hyperparathyroidism.The Journal of endocrinology · 2011Article
- Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells.Nature neuroscience · 2011Article
- Interaction between Hhex and SOX13 modulates Wnt/TCF activity.The Journal of biological chemistry · 2010Article
- Calcium-sensing receptor expression is regulated by glial cells missing-2 in human parathyroid cells.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2009Article
- Glial cells missing homologue 1 is induced in differentiating equine chorionic girdle trophoblast cells.Biology of reproduction · 2009Article
- Dominant-negative GCMB mutations cause an autosomal dominant form of hypoparathyroidism.The Journal of clinical endocrinology and metabolism · 2008Article
- Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth.Development (Cambridge, England) · 2008Article
- bZIP-Type transcription factors CREB and OASIS bind and stimulate the promoter of the mammalian transcription factor GCMa/Gcm1 in trophoblast cells.Nucleic acids research · 2008Article
- Influenza A virus transactivates the mouse envelope gene encoding syncytin B and its regulator, glial cells missing 1.Journal of neurovirology · 2007Article
- Huckebein-mediated autoregulation of Glide/Gcm triggers glia specification.The EMBO journal · 2006Article
- Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.Molecular and cellular biology · 2005Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Absence or presence of glial cells missing (GCM) in cells of the developing nervous system of Drosophila decides over their future fate as neurons or glia with only those cells turning into glia that express GCM. To understand how GCM exerts its function we performed a detailed structure-function analysis. Using fusions between the DNA binding domain of the yeast GAL4 protein and GCM, we detected a transactivation function within the C-terminal part of GCM. In addition to this transactivation domain we mapped a sequence-specific DNA-binding domain within the N-terminal part of the GCM protein in close proximity to a bipartite nuclear localization signal. Binding site selection assays determined the motif 5'-AT(G/A)CGGGT-3' as the preferred binding site for GCM. Both the lack of homology to known proteins and the novel DNA binding specificity indicate that GCM contained a new type of DNA-binding domain. In transiently transfected cells, GCM also activated transcription from promoters consisting of the newly identified GCM-binding site and a TATA box. Thus, GCM is a novel type of transcription factor involved in early gliogenesis.
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