ArticleProceedings of the National Academy of Sciences of the United States of America1997
A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replication.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 91 citations in OpenAlex.
- Article
- Different classes of genomic inserts contribute to human antibody diversity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Fragile sites, chromosomal lesions, tandem repeats, and disease.Frontiers in genetics · 2022Review
- Alternative DNA StructuresMicrobiology and molecular biology reviews : MMBR · 2021Review
- Chromosomal coordination and differential structure of asynchronous replicating regions.Nature communications · 2021Article
- Common Threads: Aphidicolin-Inducible and Folate-Sensitive Fragile Sites in the Human Genome.Frontiers in genetics · 2021Review
- Preferential Breakpoints in the Recovery of Broken Dicentric Chromosomes in Drosophila melanogaster.Genetics · 2015Article
- Cell line differences in replication timing of human glutamate receptor genes and other large genes associated with neural disease.Epigenetics · 2014Article
- Article
- Genome-wide copy number profiling of single cells in S-phase reveals DNA-replication domains.Nucleic acids research · 2013Article
- DNA instability at chromosomal fragile sites in cancer.Current genomics · 2010Article
- Mechanisms of genomic instabilities underlying two common fragile-site-associated loci, PARK2 and DMD, in germ cell and cancer cell lines.American journal of human genetics · 2010Article
- Secondary structure formation and DNA instability at fragile site FRA16B.Nucleic acids research · 2010Article
- DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells.Oncogene · 2010Article
- Sequencing newly replicated DNA reveals widespread plasticity in human replication timing.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Temporal differences in DNA replication during the S phase using single fiber analysis of normal human fibroblasts and glioblastoma T98G cells.Cell cycle (Georgetown, Tex.) · 2009Article
- Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence.PloS one · 2009Article
- Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites.BMC genomics · 2009Article
- Mapping of an origin of DNA replication in the promoter of fragile X gene FMR1.Experimental and molecular pathology · 2007Article
- Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The timing of DNA replication in the Xq27 portion of the human X chromosome was studied in cells derived from normal and fragile X males to further characterize the replication delay on fragile X chromosomes. By examining a number of sequence-tagged sites (STSs) that span several megabases of Xq27, we found this portion of the normal active X chromosome to be composed of two large zones with different replication times in fibroblasts, lymphocytes, and lymphoblastoid cells. The centromere-proximal zone replicates very late in S, whereas the distal zone normally replicates somewhat earlier and contains FMR1, the gene responsible for fragile X syndrome when mutated. Our analysis of the region of delayed replication in fragile X cells indicates that it extends at least 400 kb 5' of FMR1 and appears to merge with the normal zone of very late replication in proximal Xq27. The distal border of delayed replication varies among different fragile X males, thereby defining three replicon-sized domains that can be affected in fragile X syndrome. The distal boundary of the largest region of delayed replication is located between 350 and 600 kb 3' of FMR1. This example of variable spreading of late replication into multiple replicons in fragile X provides a model for the spread of inactivation associated with position-effect variegation or X chromosome inactivation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.