ArticleJournal of neurology1997
Autonomic function in narcolepsy: power spectrum analysis of heart rate variability.
Article in Journal of neurology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 47 citations in OpenAlex.
- EEG-tomographic studies with LORETA on vigilance differences between narcolepsy patients and controls and subsequent double-blind, placebo-controlled studies with modafinil.Journal of neurology · 2004Trial
- Autonomic cardiovascular control is unaffected in children referred for assessment of excessive daytime sleepiness.Journal of sleep research · 2025Article
- Cardiorespiratory changes associated with micro-arousals during naps.Neurobiology of sleep and circadian rhythms · 2023Article
- Autonomic symptoms, cardiovascular and sudomotor evaluation in de novo type 1 narcolepsy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Article
- Neurological Sleep Disorders and Blood Pressure: Current Evidence.Hypertension (Dallas, Tex. : 1979) · 2019Review
- The link between narcolepsy and autonomic cardiovascular dysfunction: a translational perspective.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- Challenges in the development of therapeutics for narcolepsy.Progress in neurobiology · 2017Review
- Plasma obestatin and autonomic function are altered in orexin-deficient narcolepsy, but ghrelin is unchanged.Endocrine · 2013Article
- Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy.Sleep · 2013Article
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- Increased heart rate variability but normal resting metabolic rate in hypocretin/orexin-deficient human narcolepsy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ten narcoleptic patients that had never been treated previously and ten healthy volunteers of comparable age underwent 48-h polygraphic recording to assess the effects of wakefulness and sleep on beat-to-beat heart rate variability by means of power spectrum analysis. The study revealed decreased power in the low frequencies (LF) during sleep (whereby an increase of the power in this band is associated with sympathetic activation) compared with wakefulness, with minimal values during stage 3-4 non-REM sleep and higher levels during REM sleep, both in patients and controls. Significantly reduced power in high frequencies (HF; mainly expression of parasympathetic control) and a significantly increased LF/HF ratio during wakefulness before sleep in narcoleptics compared with controls were found. Our study excludes a primary disturbance of cardiac autonomic nervous system in narcoleptics but suggests an altered circadian autonomic function in these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.