ReviewMolecular biology reports1996
The interaction of C-reactive protein and serum amyloid P component with nuclear antigens.
Review in Molecular biology reports, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 103 citations in OpenAlex.
- Role of serum high-sensitive C-reactive protein to predict severity of pre-eclampsia in a high-population resource-poor country: a prospective observational study.Journal of rural medicine : JRM · 2025Article
- Monomeric C-Reactive Protein in Atherosclerotic Cardiovascular Disease: Advances and Perspectives.International journal of molecular sciences · 2023Review
- Zebrafish C-reactive protein isoforms inhibit SVCV replication by blocking autophagy through interactions with cell membrane cholesterol.Scientific reports · 2020Article
- Therapeutic Lowering of C-Reactive Protein.Frontiers in immunology · 2020Review
- The Development of Serum Amyloid P as a Possible Therapeutic.Frontiers in immunology · 2018Review
- Pentraxins and Fc Receptor-Mediated Immune Responses.Frontiers in immunology · 2018Review
- Human Pentraxins Bind to Misfolded Proteins and Inhibit Production of Type I Interferon Induced by Nucleic Acid-Containing Amyloid.Journal of clinical & cellular immunology · 2015Article
- Absence of FcγRIII results in increased proinflammatory response in FcγRIII-KO cardiac recipients.Transplantation · 2013Article
- Pentraxins: structure, function, and role in inflammation.ISRN inflammation · 2013Review
- A Comparative Study of Serum Level of Vascular Cell Adhesion Molecule-1 (sVCAM-1), Intercellular Adhesion Molecule-1(ICAM-1) and High Sensitive C - reactive protein (hs-CRP) in Normal and Pre-eclamptic Pregnancies.Iranian journal of basic medical sciences · 2013Article
- A comparative study of vascular cell adhesion molecule-1 and high-sensitive C-reactive protein in normal and preeclamptic pregnancies.Interventional medicine & applied science · 2013Article
- Pentraxins and Fc receptors.Immunological reviews · 2012Review
- SAP suppresses the development of experimental autoimmune encephalomyelitis in C57BL/6 mice.Immunology and cell biology · 2012Article
- Pentraxins (CRP, SAP) in the process of complement activation and clearance of apoptotic bodies through Fcγ receptors.Current opinion in organ transplantation · 2011Review
- Pentraxins, anti-pentraxin antibodies, and atherosclerosis.Clinical reviews in allergy & immunology · 2009Review
- Macrophages activated by C-reactive protein through Fc gamma RI transfer suppression of immune thrombocytopenia.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Pattern recognition by pentraxins.Advances in experimental medicine and biology · 2009Review
- Dietary modulation and structure prediction of rat mucosal pentraxin (Mptx) protein and loss of function in humans.Genes & nutrition · 2007Article
- Anti-serum amyloid component P antibodies in patients with systemic lupus erythematosus correlate with disease activity.Annals of the rheumatic diseases · 2005Article
- Protective molecules--C-reactive protein (CRP), serum amyloid P (SAP), pentraxin3 (PTX3), mannose-binding lectin (MBL), and apolipoprotein A1 (Apo A1), and their autoantibodies: prevalence and clinical significance in autoimmunity.Journal of clinical immunology · 2005Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The pentraxins are a family of proteins characterized by cyclic pentameric structure, calcium-dependent ligand binding and sequence homology. The two main representatives of this family are the serum proteins, C-reactive protein (CRP) and serum amyloid P component (SAP). In man CRP is an acute phase reactant which increases up to 1,000 fold during the acute phase response whereas SAP is a constitutive protein expressed at about 30 micrograms/ml. These proteins activate complement through the classical pathway and participate in opsonization of particulate antigens and bacteria. In the past several years it has been determined that both of these pentraxins interact with nuclear antigens including chromatin and small nuclear ribonucleoproteins (snRNPs). Both CRP and SAP have nuclear transport signals which facilitate their entry into the nuclei of intact cells. Furthermore, these pentraxins have been shown to affect the clearance of nuclear antigens in vivo. It is now believed that one of the major functions of the pentraxins could be to interact with the nuclear antigens released from apoptotic or necrotic cells. This interaction could mitigate against deposition of these antigens in tissue and autoimmune reactivity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.