ArticleMolecular and cellular biology1997
POU domain factors of the Brn-3 class recognize functional DNA elements which are distinctive, symmetrical, and highly conserved in evolution.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Novel Variant Identified in the Enhancer Region of Host Transcription Factor, BRN3A, is a Significant Risk Factor for HPV-Induced Uterine Cervix Cancer.International journal of molecular and cellular medicine · 2022Article
- Article
- Genetic control of retinal ganglion cell genesis.Cellular and molecular life sciences : CMLS · 2021Review
- Linking metabolic dysfunction with cardiovascular diseases: Brn-3b/POU4F2 transcription factor in cardiometabolic tissues in health and disease.Cell death & disease · 2021Review
- A MissenseBioMed research international · 2021Article
- Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart.Cell death & disease · 2017Article
- The lncRNA SLNCR1 Mediates Melanoma Invasion through a Conserved SRA1-like Region.Cell reports · 2016Article
- Cis-regulatory mechanisms for robust olfactory sensory neuron class-restricted odorant receptor gene expression in Drosophila.PLoS genetics · 2015Article
- Activation of Six1 Expression in Vertebrate Sensory Neurons.PloS one · 2015Article
- Article
- Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells.PloS one · 2014Article
- The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival.EMBO molecular medicine · 2013Article
- RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors.Molecular vision · 2013Article
- Expression of hindbrain boundary markers is regulated by FGF3.Biology open · 2012Article
- Mouse transgenesis identifies conserved functional enhancers and cis-regulatory motif in the vertebrate LIM homeobox gene Lhx2 locus.PloS one · 2011Article
- Early B-cell factors are required for specifying multiple retinal cell types and subtypes from postmitotic precursors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation.Neural development · 2010Article
- Towards an understanding of the herpes simplex virus type 1 latency-reactivation cycle.Interdisciplinary perspectives on infectious diseases · 2010Article
- Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment.PLoS genetics · 2009Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
To better understand the diversity of function within the POU domain class of transcriptional regulators, we have determined the optimal DNA recognition site of several proteins of the POU-IV (Brn-3) subclass by random oligonucleotide selection. The consensus recognition element derived in this study, ATAATTAAT, is clearly distinct from octamer sites described for the POU factor Oct-1. The optimal POU-IV site determined here also binds Brn-3.0 with significantly higher affinity than consensus recognition sites previously proposed for this POU subclass. The binding affinity of Brn-3.0 on its optimal site, several variants of this site, and several naturally occurring POU recognition elements is highly correlated with the activation of reporter gene expression by Brn-3.0 in transfection assays. The preferred DNA recognition site of Brn-3.0 resembles strongly the optimal sites of another mammalian POU-IV class protein, Brn-3.2, and of the Caenorhabditis elegans Brn-3.0 homolog Unc-86, demonstrating that the site-specific DNA recognition properties of these factors are highly conserved between widely divergent species.
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