ArticleThe Journal of clinical investigation1997
Antibody to VLA-4, but not to L-selectin, protects neuronal M2 muscarinic receptors in antigen-challenged guinea pig airways.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 87 citations in OpenAlex.
- Physiological and immunological aspects of asthma: the guinea pig (Cavia porcellus) as a model of allergic asthma.Laboratory animal research · 2025Review
- Eosinophils prevent diet-induced airway hyperresponsiveness in mice on a high-fat diet.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Neuro-Immune Regulation in Inflammation and Airway Remodeling of Allergic Asthma.Frontiers in immunology · 2022Review
- Airway Sensory Nerve Plasticity in Asthma and Chronic Cough.Frontiers in physiology · 2021Review
- Inflammatory mechanisms linking maternal and childhood asthma.Journal of leukocyte biology · 2020Review
- Lung eosinophils increase vagus nerve-mediated airway reflex bronchoconstriction in mice.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma.American journal of physiology. Lung cellular and molecular physiology · 2018Review
- Eosinophils increase airway sensory nerve density in mice and in human asthma.Science translational medicine · 2018Article
- Eosinophil and airway nerve interactions in asthma.Journal of leukocyte biology · 2018Review
- Protective Role of Eosinophils and TNFa after Ozone Inhalation.Research report (Health Effects Institute) · 2017Article
- Activated eosinophils in association with enteric nerves in inflammatory bowel disease.PloS one · 2013Article
- Three protein cocktails mediate delayed-type hypersensitivity responses indistinguishable from that elicited by purified protein derivative in the guinea pig model of Mycobacterium tuberculosis infection.Infection and immunity · 2011Article
- Kinetics of the immune response profile in guinea pigs after vaccination with Mycobacterium bovis BCG and infection with Mycobacterium tuberculosis.Infection and immunity · 2009Article
- Atropine-enhanced, antigen challenge-induced airway hyperreactivity in guinea pigs is mediated by eosinophils and nerve growth factor.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Relationships between eosinophilic inflammation, tissue remodeling, and fibrosis in eosinophilic esophagitis.Immunology and allergy clinics of North America · 2009Review
- Etanercept prevents airway hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs.British journal of pharmacology · 2009Article
- Mechanisms of eosinophilia in the pathogenesis of hypereosinophilic disorders.Immunology and allergy clinics of North America · 2007Review
- Allergic rhinitis/asthma interrelationships.Clinical reviews in allergy & immunology · 2001Review
- Reciprocal immunomodulatory effects of gamma interferon and interleukin-4 on filaria-induced airway hyperresponsiveness.Infection and immunity · 2001Article
- alpha(4) integrin-dependent eosinophil recruitment in allergic but not non-allergic inflammation.British journal of pharmacology · 2001Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Antigen challenge of sensitized guinea pigs decreases the function of inhibitory M2 muscarinic autoreceptors on parasympathetic nerves in the lung, potentiating vagally induced bronchoconstriction. Loss of M2 receptor function is associated with the accumulation of eosinophils around airway nerves. To determine whether recruitment of eosinophils via expression of VLA-4 and L-selectin is critical for loss of M2 receptor function, guinea pigs were pretreated with monoclonal antibodies to VLA-4 (HP1/2) or L-selectin (LAM1-116). Guinea pigs were sensitized and challenged with ovalbumin, and M2 receptor function was tested. In controls, blockade of neuronal M2 muscarinic receptors by gallamine potentiated vagally induced bronchoconstriction, while in challenged animals this effect was markedly reduced, confirming M2 receptor dysfunction. Pretreatment with HP1/2, but not with LAM1-116, protected M2 receptor function in the antigen-challenged animals. HP1/2 also inhibited the development of hyperresponsiveness, and selectively inhibited accumulation of eosinophils in the lungs as measured by lavage and histology. Thus, inhibition of eosinophil influx into the lungs protects the function of M2 muscarinic receptors, and in so doing, prevents hyperresponsiveness in antigen-challenged guinea pigs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.