ArticleThe Journal of clinical investigation1997
Gene rearrangement: a novel mechanism for MDR-1 gene activation.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 98 citations in OpenAlex.
- Multidrug Resistance: Are We Still Afraid of the Big Bad Wolf.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Oncofusions - shaping cancer care.The oncologist · 2025Article
- Review
- Enhanced anticancer activity of combined treatment of imatinib and dipyridamole in solid Ehrlich carcinoma-bearing mice.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target.Cancers · 2020Review
- Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer: In vitro and in vivo study.Cancer letters · 2017Article
- Comparative Aspects of Molecular Mechanisms of Drug Resistance through ABC Transporters and Other Related Molecules in Canine Lymphoma.Veterinary sciences · 2015Review
- Article
- Non-Darwinian dynamics in therapy-induced cancer drug resistance.Nature communications · 2013Article
- Prediction of Therapy Response and Prognosis in Leukemias by Flow Cytometric MDR Assays.EJIFCC · 2013Article
- Elevated level of lysine 9-acetylated histone H3 at the MDR1 promoter in multidrug-resistant cells.Cancer science · 2012Article
- Article
- Molecular mechanisms of drug resistance in single-step and multi-step drug-selected cancer cells.Methods in molecular biology (Clifton, N.J.) · 2010Article
- Regulation of ABCG2 expression at the 3' untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line.Molecular and cellular biology · 2008Article
- A thermally targeted elastin-like polypeptide-doxorubicin conjugate overcomes drug resistance.Investigational new drugs · 2007Article
- Function-altering SNPs in the human multidrug transporter gene ABCB1 identified using a Saccharomyces-based assay.PLoS genetics · 2007Article
- Characterization of the human MDR1 gene.The AAPS journal · 2005Article
- Article
- The MDR1 (ABCB1) gene polymorphism and its clinical implications.Clinical pharmacokinetics · 2004Review
- Transcriptional regulation of ABC drug transporters.Oncogene · 2003Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug resistance, a major obstacle to cancer chemotherapy, can be mediated by MDR-1/P-glycoprotein. Deletion of the first 68 residues of MDR-1 in an adriamycin-selected cell line after a 4;7 translocation, t(4q;7q), resulted in a hybrid mRNA containing sequences from both MDR-1 and a novel chromosome 4 gene. Further selection resulted in amplification of a hybrid gene. Expression of the hybrid mRNA was controlled by the chromosome 4 gene, providing a model for overexpression of MDR-1. Additional hybrid mRNAs in other drug-selected cell lines and in patients with refractory leukemia, with MDR-1 juxtaposed 3' to an active gene, establishes random chromosomal rearrangements with overexpression of hybrid MDR-1 mRNAs as a mechanism of acquired drug resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.