ArticleThe Journal of clinical investigation1997
Clinical role for a superantigen in Yersinia pseudotuberculosis infection.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 83 citations in OpenAlex.
- Yersinia pseudotuberculosis infection in Kawasaki disease and its clinical characteristics.BMC pediatrics · 2015Trial
- Article
- Article
- Genome Analysis of Japanese Yersinia pseudotuberculosis Strains Isolated From Kawasaki Disease Patients and Other Sources and Their Phylogenetic Positions in the Global Y. pseudotuberculosis Population.Microbiology and immunology · 2025Article
- Yersinia pseudotuberculosis-Associated Myositis.Cureus · 2024Article
- Emerging evidence of microbial infection in causing systematic immune vasculitis in Kawasaki disease.Frontiers in microbiology · 2023Review
- Article
- Far East Scarlet-like Fever Masquerading as Adult-onset Kawasaki Disease.Internal medicine (Tokyo, Japan) · 2018Article
- Kawasaki Disease Presenting with Bloody Diarrhea and Acute Renal Failure: First Case.Pediatric reports · 2017Article
- Superantigenic Yersinia pseudotuberculosis induces the expression of granzymes and perforin by CD4+ T cells.Infection and immunity · 2015Article
- A Child With Kawasaki Disease and Yersinia enterocolitica Infection: A Closer Look at Pathogenesis.Global pediatric health · 2015Article
- Kidney and urinary tract involvement in kawasaki disease.International journal of pediatrics · 2013Review
- Pathogenic characterization of a cervical lymph node derived from a patient with Kawasaki disease.International journal of clinical and experimental pathology · 2012Article
- High affinity of interaction between superantigen and T cell receptor Vbeta molecules induces a high level and prolonged expansion of superantigen-reactive CD4+ T cells.The Journal of biological chemistry · 2010Article
- Vasculitis induced by immunization with Bacillus Calmette-Guérin followed by atypical mycobacterium antigen: a new mouse model for Kawasaki disease.FEMS immunology and medical microbiology · 2007Article
- Mesenteric adenitis caused by Yersinia pseudotubercolosis in a patient subsequently diagnosed with Crohn's disease of the terminal ileum.World journal of gastroenterology · 2006Article
- Expression of CD180, a toll-like receptor homologue, is up-regulated in children with Kawasaki disease.Journal of molecular medicine (Berlin, Germany) · 2006Article
- Yersinia pseudotuberculosis septicemia and HIV.Emerging infectious diseases · 2005Article
- Acute renal failure in Kawasaki disease.Pediatric nephrology (Berlin, Germany) · 2003Article
- Pseudomonas fluorescens encodes the Crohn's disease-associated I2 sequence and T-cell superantigen.Infection and immunity · 2002Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yersinia pseudotuberculosis is an enteric pathogen that causes a variety of clinical symptoms in the human. Recently, we reported the production of a superantigen (Y. pseudotuberculosis-derived mitogen, YPM) by this organism and characterized the gene structure of ypm. To further study the potential pathogenic role of YPM in Y. pseudotuberculosis infection, we assayed IgG anti-YPM antibodies and T cell antigen receptor-Vbeta expression of the T cells in peripheral blood and in mesenteric lymph node in patients acutely infected with Y. pseudotuberculosis. 20 out of 33 patients (61%) had an elevated antibody titer compared with healthy controls (P = 0.0001). Patients with systemic symptoms such as lymphadenopathy, transient renal dysfunction, and arthritis had significantly higher titers of anti-YPM than patients with gastrointestinal tract symptoms alone. T cells bearing the Vbeta3 gene segment were significantly increased (P = 0.009) among acute phase patients compared with healthy children. During the convalescence phase of the illness, there was a reduction in the abnormal level of Vbeta3 T cells. Moreover, in the mesenteric lymph node, an elevated level of Vbeta3 T cells compared with peripheral blood and a sequence diversity in the junctional region of the T cell antigen receptor beta-chain containing Vbeta3 element was observed in one patient. Together, these findings suggest that YPM was produced in vivo and played an important role in the pathogenesis of Y. pseudotuberculosis infection.
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