ArticleNucleic acids research1997
The major transcription initiation site of the SV40 late promoter is a potent thyroid hormone response element.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Reversing thyroid-hormone-mediated repression of a HSV-1 promoter via computationally guided mutagenesis.Journal of cell science · 2017Article
- The adenovirus 55 residue E1A protein is a transcriptional activator and binds the unliganded thyroid hormone receptor.The Journal of general virology · 2014Article
- Corepressor/coactivator paradox: potential constitutive coactivation by corepressor splice variants.Nuclear receptor signaling · 2006Article
- Cell type-specific replication of simian virus 40 conferred by hormone response elements in the late promoter.Journal of virology · 2002Article
- Regulation of the juvenile hormone esterase gene by a composite core promoter.The Biochemical journal · 2000Article
- Transcription of the juvenile hormone esterase gene under the control of both an initiator and AT-rich motif.The Biochemical journal · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid hormone receptors (TRs) are members of the nuclear hormone receptor superfamily, which act as transcription factors upon binding to specific DNA sequences called thyroid hormone (T3) response elements (TREs). Such elements are found in the upstream regulatory region of promoters as well as in intragenic sequences of T3-responsive genes. In this report, we demonstrate that SV40 late (SVL) promoter activity is strongly down-regulated by TR in the absence of ligand. Addition of T3 releases this repression, but does not further induce SVL promoter activity. Electrophoretic mobility shift analyses reveal a TR binding element that overlaps with the SV40 major late transcription initiation site. This element closely fits the consensus TRE, formed of two hexanucleotides organized in a tandem repeat separated by 4 nt, and is able to confer T3 responsiveness on a heterologous promoter. We further show that, although the presence of TR leads to quantitatively modified expression of an SVL-driven reporter gene, neither displacement of the site of transcription initiation nor modification of the splicing pattern of the primary transcripts occur.
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