ArticleProceedings of the National Academy of Sciences of the United States of America1997
Target-independent cholinergic differentiation in the rat sympathetic nervous system.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
- Molecular and functional diversity of the autonomic nervous system.Nature reviews. Neuroscience · 2025Review
- A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.Cell stem cell · 2022Article
- Frey's syndrome: A review of the physiology and possible role of neurotrophic factors.Laryngoscope investigative otolaryngology · 2021Article
- Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies.Nature communications · 2019Article
- Alpha-Synuclein Deposition Within Sympathetic Noradrenergic Neurons Is Associated With Myocardial Noradrenergic Deficiency in Neurogenic Orthostatic Hypotension.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Myocardial Infarction Causes Transient Cholinergic Transdifferentiation of Cardiac Sympathetic Nerves via gp130.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Satb2-independent acquisition of the cholinergic sudomotor phenotype in rodents.Cellular and molecular neurobiology · 2015Article
- Chemical coding and chemosensory properties of cholinergic brush cells in the mouse gastrointestinal and biliary tract.Frontiers in physiology · 2015Article
- Cholinergic epithelial cell with chemosensory traits in murine thymic medulla.Cell and tissue research · 2014Article
- Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen.The Journal of comparative neurology · 2013Article
- Tlx3 controls cholinergic transmitter and Peptide phenotypes in a subset of prenatal sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Localization and expression of VMAT2 aross mammalian species: a translational guide for its visualization and targeting in health and disease.Advances in pharmacology (San Diego, Calif.) · 2013Review
- A distinct trans-Golgi network subcompartment for sorting of synaptic and granule proteins in neurons and neuroendocrine cells.Journal of cell science · 2011Article
- The sympathetic neurotransmitter switch depends on the nuclear matrix protein Satb2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Neurotrophins and target interactions in the development and regulation of sympathetic neuron electrical and synaptic properties.Autonomic neuroscience : basic & clinical · 2009Review
- Sweat gland innervation is pioneered by sympathetic neurons expressing a cholinergic/noradrenergic co-phenotype in the mouse.Neuroscience · 2008Article
- Sympathetic sprouting drives hippocampal cholinergic reinnervation that prevents loss of a muscarinic receptor-dependent long-term depression at CA3-CA1 synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Coexpression of cholinergic and noradrenergic phenotypes in human and nonhuman autonomic nervous system.The Journal of comparative neurology · 2005Article
- Immunocytochemical properties of stellate ganglion neurons during early postnatal development.Histochemistry and cell biology · 2004Article
- Neurotrophin-3 promotes the cholinergic differentiation of sympathetic neurons.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemical coding in the sympathetic nervous system involves both noradrenergic and, for a minority of neurons, cholinergic neurotransmission. The expression of the cholinergic phenotype in the developing sympathetic nervous system was examined to determine if coding for cholinergic transmission occurs before or after innervation of peripheral target organs. The vesicular acetylcholine transporter (VAChT) and choline acetyltransferase, the products of the "cholinergic gene locus" determining the cholinergic phenotype, were expressed in principal cells of the paravertebral, but only rarely in prevertebral, sympathetic chains as early as embryonic day 14. A subpopulation of VAChT- and choline acetyltransferase-positive sympathetic ganglion cells persisted throughout development of the stellate and more caudal paravertebral ganglia into anatomically distinct cell groups, and into adulthood. The forepaw eccrine sweat glands, innervated exclusively by the stellate ganglion, received VAChT-positive nerve terminals at least as early as postembryonic day 4, coincident with the development of the sweat glands themselves. These terminals, like the VAChT-positive cell bodies of the developing stellate ganglion, have some noradrenergic traits including expression of tyrosine hydroxylase, but did not express the vesicular monoamine transporter, and are therefore not functionally noradrenergic. Development of the cholinergic phenotype in principal cells of the sympathetic paravertebral ganglia apparently occurs via receipt of instructive cues, or selection, within the sympathetic chain itself or perhaps even during migration of the cells of the neural crest from which the paravertebral ganglia arise.
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