ArticleProceedings of the National Academy of Sciences of the United States of America1997
Specific chromosomal imbalances in human papillomavirus-transfected cells during progression toward immortality.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 87 citations in OpenAlex.
- ITIH5 shows tumor suppressive properties in cervical cancer cells grown as multicellular tumor spheroids.American journal of translational research · 2021Article
- Expression of the HPV18/E6 oncoprotein induces DNA damage.European journal of histochemistry : EJH · 2017Article
- The Rb binding domain of HPV31 E7 is required to maintain high levels of DNA repair factors in infected cells.Virology · 2017Article
- Immortalization capacity of HPV types is inversely related to chromosomal instability.Oncotarget · 2016Article
- Establishment of a patient-derived orthotopic osteosarcoma mouse model.Journal of translational medicine · 2015Article
- SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes.BMC cancer · 2013Article
- Genomic Instability Induced By Human Papillomavirus Oncogenes.North American journal of medicine & science · 2010Article
- Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia.Leukemia · 2009Article
- Human papillomavirus (HPV) type 18 induces extended growth in primary human cervical, tonsillar, or foreskin keratinocytes more effectively than other high-risk mucosal HPVs.Journal of virology · 2009Article
- Human Papilloma Virus (HPV) in head and neck region: review of literature.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2009Review
- Integration of the HPV16 genome does not invariably result in high levels of viral oncogene transcripts.Oncogene · 2008Article
- Microarray comparative genomic hybridization detection of chromosomal imbalances in uterine cervix carcinoma.BMC cancer · 2005Article
- Clonal selection for transcriptionally active viral oncogenes during progression to cancer.Journal of virology · 2004Article
- Pathogenesis of human papillomaviruses in differentiating epithelia.Microbiology and molecular biology reviews : MMBR · 2004Review
- Article
- Changes in retinoblastoma gene expression during cervical cancer progression.International journal of experimental pathology · 2002Article
- The human papillomavirus type 16 E6 oncogene induces premature mitotic chromosome segregation.Oncogene · 2002Article
- Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability.Oncogene · 2002Review
- Interference of papillomavirus E6 protein with single-strand break repair by interaction with XRCC1.The EMBO journal · 2002Article
- Down-regulation of GATA-3 expression during human papillomavirus-mediated immortalization and cervical carcinogenesis.The American journal of pathology · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High risk human papillomaviruses (HPVs) known to be closely associated with cervical cancer, such as HPV16 and HPV18, have the potential to immortalize human epithelial cells in culture. Four lines of HPV-transfected keratinocytes were analyzed by comparative genomic hybridization at different time points after transfection. A number of chromosomal imbalances was found to be highly characteristic for the cultures progressing toward immortality. Whereas several of these were new and previously not found as recurrent aberrations in cervical tumors, some were identical to chromosomal changes observed during cervical carcinogenesis. The data put new emphasis on the studied cell system as a relevant model for HPV-induced pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.