ArticleProceedings of the National Academy of Sciences of the United States of America1997
Nucleolin is one component of the B cell-specific transcription factor and switch region binding protein, LR1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 129 citations in OpenAlex.
- Nucleolus and centromere Tyramide Signal Amplification-Seq reveals variable localization of heterochromatin in different cell types.Communications biology · 2024Article
- COPI coatomer subunit α-COP interacts with the RNA binding protein Nucleolin via a C-terminal dilysine motif.Human molecular genetics · 2023Article
- G4-quadruplex-binding proteins: review and insights into selectivity.Biophysical reviews · 2022Review
- Integrated analysis of mRNA and miRNA expression in HeLa cells expressing low levels of Nucleolin.Scientific reports · 2017Article
- Regulation of nucleolin expression by miR-194, miR-206, and HuR.Molecular and cellular biochemistry · 2016Article
- Control of AC133/CD133 and impact on human hematopoietic progenitor cells through nucleolin.Leukemia · 2015Article
- Nucleolin is important for Epstein-Barr virus nuclear antigen 1-mediated episome binding, maintenance, and transcription.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Induced expression of nucleolin phosphorylation-deficient mutant confers dominant-negative effect on cell proliferation.PloS one · 2014Article
- Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production.PLoS genetics · 2013Article
- The pseudopeptide HB-19 binds to cell surface nucleolin and inhibits angiogenesis.Vascular cell · 2012Article
- Cotinine-conjugated aptamer/anti-cotinine antibody complexes as a novel affinity unit for use in biological assays.Experimental & molecular medicine · 2012Article
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- Nucleolin: The most abundant multifunctional phosphoprotein of nucleolus.Communicative & integrative biology · 2011Article
- The C-terminus of nucleolin promotes the formation of the c-MYC G-quadruplex and inhibits c-MYC promoter activity.Biochemistry · 2010Article
- Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5.Transcription · 2010Article
- A new paradigm for aptamer therapeutic AS1411 action: uptake by macropinocytosis and its stimulation by a nucleolin-dependent mechanism.Cancer research · 2010Article
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- The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization.Nucleic acids research · 2010Article
- Molecular and cellular evidence for biased mitotic gene conversion in hybrid scallop.BMC evolutionary biology · 2010Article
- AUF1 is involved in splenic follicular B cell maintenance.BMC immunology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
LR1 is a B cell-specific, sequence-specific DNA binding activity that regulates transcription in activated B cells. LR1 also binds Ig heavy chain switch region sequences and may function in class switch recombination. LR1 contains two polypeptides, of 106 kDa and 45 kDa, and here we report that the 106-kDa component of LR1 is nucleolin. This identification, initially made by microsequence analysis, was verified by showing that (i) LR1-DNA binding activity increased in B cells transfected with a nucleolin cDNA expression construct; (ii) LR1-DNA binding activity was recognized by antibodies raised against recombinant human nucleolin; and (iii) in B cells transfected with epitope-tagged nucleolin expression constructs, the LR1-DNA complex was recognized by the anti-tag antibody. Nucleolin is an abundant nucleolar protein which is believed to play a role in rDNA transcription or organization, or rRNA processing. Homology between nucleolin and histone H1 suggests that nucleolin may alter DNA organization in response to cell cycle controls, and the nucleolin component of LR1 may therefore function to organize switch regions before, during, or after switch recombination. The demonstration that nucleolin is a component of a B cell-specific complex that binds switch region sequences suggests that the G-rich switch regions may have evolved from rDNA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.