ArticleMammalian genome : official journal of the International Mammalian Genome Society1997
Characterization, chromosomal localization, and genetic variation of the porcine heart fatty acid-binding protein gene.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 114 citations in OpenAlex.
- Effect of Excessive or Restrictive Energy on Growth Performance, Meat Quality, and Intramuscular Fat Deposition in Finishing Ningxiang Pigs.Animals : an open access journal from MDPI · 2020Article
- Association of Twelve Candidate Gene Polymorphisms with the Intramuscular Fat Content and Average Backfat Thickness of Chinese Suhuai Pigs.Animals : an open access journal from MDPI · 2019Article
- Assessment of meat quality defect genes in indigenous pigs of Bareilly region.Tropical animal health and production · 2019Article
- Polymorphism distribution of RYR1, PRKAG3, HFABP, MYF-5 and MC4R genes in crossbred pigs.Molecular biology reports · 2018Article
- Altered epidermal fatty acid-binding protein expression in hepatocellular carcinoma predicts unfavorable outcomes.Cancer management and research · 2018Article
- Tissue expression analysis, cloning and characterization of the 5'-regulatory region of the bovine FABP3 gene.Molecular biology reports · 2016Article
- Genomic signatures reveal new evidences for selection of important traits in domestic cattle.Molecular biology and evolution · 2015Article
- Association between subcutaneous and intramuscular fat content in porcine ham and loin depending on age, breed and FABP3 and LEPR genes transcript abundance.Molecular biology reports · 2013Article
- Expression levels of candidate genes for intramuscular fat deposition in two Banna mini-pig inbred lines divergently selected for fatness traits.Genetics and molecular biology · 2012Article
- Distribution and linkage disequilibrium analysis of polymorphisms of MC4R, LEP, H-FABP genes in the different populations of pigs, associated with economic traits in DIV2 line.Molecular biology reports · 2012Article
- Association of genetic variants for FABP3 gene with back fat thickness and intramuscular fat content in pig.Molecular biology reports · 2011Article
- The human fatty acid-binding protein family: evolutionary divergences and functions.Human genomics · 2011Review
- Article
- Investigation of porcine FABP3 and LEPR gene polymorphisms and mRNA expression for variation in intramuscular fat content.Molecular biology reports · 2010Article
- Article
- Regression-based approach for testing the association between multi-region haplotype configuration and complex trait.BMC genetics · 2009Article
- A critical analysis of production-associated DNA polymorphisms in the genes of cattle, goat, sheep, and pig.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Review
- The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism.Journal of applied genetics · 2006Review
- Induction of cardiac FABP gene expression by long chain fatty acids in cultured rat muscle cells.Molecular and cellular biochemistry · 2001Article
- Genome-wide scan for body composition in pigs reveals important role of imprinting.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to detect genetic variation in the porcine H-FABP gene, a candidate gene for meat quality traits in pigs. Lambda phages containing the porcine H-FABP gene were isolated by plaque hybridization with human H-FABP cDNA. The coding and flanking intronic sequences of the porcine H-FABP gene were determined as well as 1.6 kb of the 5' upstream region. The various potential regulatory sequences in this region are in accordance with the function and expression of the protein in muscle and mammary tissue. Furthermore, comparison with the homolog region of the mouse identified a highly conserved 13-bp element (CTTCCT [A/C] TTTCGG) that may be involved in regulation of expression. The porcine H-FABP gene was localized on Chromosome (Chr) 6 by porcine sequence-specific PCR on DNA from a pig/rodent cell hybrid panel. In addition, part of the H-FABP gene was screened for genetic variation by PCR-RFLP analysis. Three PCR-RFLPs were detected, one in the upstream region (HinfI) and two in the second intron (HaeIII and MspI). In most pig breeds the corresponding alleles have a variable distribution, possibly a consequence of selective breeding. This genetic variation will enable us to investigate the role of the H-FABP locus in porcine production and meat quality traits.
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