ArticleMammalian genome : official journal of the International Mammalian Genome Society1997
The mouse homolog of PKD1: sequence analysis and alternative splicing.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- A new conceptual framework for PKD1 in ADPKD; integrating DNA structures and inflammation.BMC nephrology · 2026Review
- Eliosin-an alternative product from the HmPKD1 locus is a component of endoplasmic reticulum mitochondria membrane contact sites.PloS one · 2025Article
- ModelingMolecular therapy. Methods & clinical development · 2023Article
- Human-Specific Abnormal Alternative Splicing of Wild-TypeJournal of the American Society of Nephrology : JASN · 2018Article
- Altered trafficking and stability of polycystins underlie polycystic kidney disease.The Journal of clinical investigation · 2014Article
- Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium.American journal of physiology. Renal physiology · 2011Article
- Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have cloned and sequenced the mouse transcript homologous to human polycystic kidney disease 1 (PKD1). The predicted protein is 79% identical to human PKD1 and shows the presence of most of the domains identified in the human sequence. Since the mouse homolog is transcribed from a unique gene and there are no transcribed, closely related copies as has been observed for human PKD1, we have been able to investigate alternative splicing of the transcript. At the junction of exons 12 and 13, several different splicing variants lead to a predicted protein that would be secreted. These forms are predominantly found in newborn brain, while in kidney the transcript homologous to the previously described human RNA predominates.
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Registered trials
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