ArticleProceedings. Biological sciences1997
Thyroid hormone regulates Na+ currents in cultured hippocampal neurons from postnatal rats.
Article in Proceedings. Biological sciences, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Deficiency of Thyroid Hormone Reduces Voltage-Gated NaInternational journal of molecular sciences · 2022Article
- Changes in Neuronal Excitability by Activated Microglia: Differential Na(+) Current Upregulation in Pyramid-Shaped and Bipolar Neurons by TNF-α and IL-18.Frontiers in neurology · 2016Article
- Regulation of neuronal excitability by release of proteins from glial cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Thyroid hormone-dependent development of early cortical networks: temporal specificity and the contribution of trkB and mTOR pathways.Frontiers in cellular neuroscience · 2013Article
- Carbon nanotube scaffolds tune synaptic strength in cultured neural circuits: novel frontiers in nanomaterial-tissue interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Thyroid hormone (T3)-induced up-regulation of voltage-activated sodium current in cultured postnatal hippocampal neurons requires secretion of soluble factors from glial cells.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Sensory neuron sodium current requires nongenomic actions of thyroid hormone during development.Journal of neurophysiology · 2008Article
- Regulation of ion channel expression in neural cells by hormones and growth factors.Molecular neurobiology · 1998Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The causes for mental retardation due to perinatal hypothyroidism are not fully understood. Here we show that the most potent component of thyroid hormone, 3,5,3'-triiodo-L-thyronine (T3), selectively increases the density of voltage-activated Na+ currents in hippocampal neurons from newborn rats. Thus, the well known effects of thyroid hormone on energy expenditure and Na+/K+ ATPase activity could to some extent result from the enhanced Na+ influx through voltage-activated Na+ channels. In addition, a down-regulation of the Na+ current density in neurons could contribute to some of the neurological symptoms accompanying hypothyroidism, including slowing of mentation, of neuronal conduction velocities, the alpha rhythm of the electroencephalogram, and increased latencies of evoked potentials and reflexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.