ArticleAmerican journal of human genetics1997
Archaic African and Asian lineages in the genetic ancestry of modern humans.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
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Who cites it
107 citing papers in PubMed.
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- SEQUENTIAL IMPORTANCE SAMPLING FOR MULTIRESOLUTION KINGMAN-TAJIMA COALESCENT COUNTING.The annals of applied statistics · 2020Article
- Hapl-o-Mat: open-source software for HLA haplotype frequency estimation from ambiguous and heterogeneous data.BMC bioinformatics · 2017Article
- Motion sickness: more than nausea and vomiting.Experimental brain research · 2014Article
- Distortion of genealogical properties when the sample is very large.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Neutral genomic regions refine models of recent rapid human population growth.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Evolutionary constraints in the β-globin cluster: the signature of purifying selection at the δ-globin (HBD) locus and its role in developmental gene regulation.Genome biology and evolution · 2013Article
- Dating human cultural capacity using phylogenetic principles.Scientific reports · 2013Article
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- Genetic variation in Native Americans, inferred from Latino SNP and resequencing data.Molecular biology and evolution · 2011Article
- Match probabilities in a finite, subdivided population.Theoretical population biology · 2011Article
- Inference from samples of DNA sequences using a two-locus model.Journal of computational biology : a journal of computational molecular cell biology · 2011Article
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- Short oligonucleotide tandem ligation assay for genotyping of single-nucleotide polymorphisms in Y chromosome.Molecular biotechnology · 2010Article
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- Multi-locus match probability in a finite population: a fundamental difference between the Moran and Wright-Fisher models.Bioinformatics (Oxford, England) · 2009Article
- Darwinian and demographic forces affecting human protein coding genes.Genome research · 2009Article
- Modeling Informatively Missing Genotypes in Haplotype Analysis.Communications in statistics: theory and methods · 2009Article
47 more citing papers are in PubMed but not listed here.
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8 authors.
Funding
Abstract
A 3-kb region encompassing the beta-globin gene has been analyzed for allelic sequence polymorphism in nine populations from Africa, Asia, and Europe. A unique gene tree was constructed from 326 sequences of 349 in the total sample. New maximum-likelihood methods for analyzing gene trees on the basis of coalescence theory have been used. The most recent common ancestor of the beta-globin gene tree is a sequence found only in Africa and estimated to have arisen approximately 800,000 years ago. There is no evidence for an exponential expansion out of a bottlenecked founding population, and an effective population size of approximately 10,000 has been maintained. Modest differences in levels of beta-globin diversity between Africa and Asia are better explained by greater African effective population size than by greater time depth. There may have been a reduction of Asian effective population size in recent evolutionary history. Characteristically Asian ancestry is estimated to be older than 200,000 years, suggesting that the ancestral hominid population at this time was widely dispersed across Africa and Asia. Patterns of beta-globin diversity suggest extensive worldwide late Pleistocene gene flow and are not easily reconciled with a unidirectional migration out of Africa 100,000 years ago and total replacement of archaic populations in Asia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.