ArticleThe Journal of cell biology1997
The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 131 citations in OpenAlex.
- The molecular mechanisms and physiological roles of mitochondria dynamics inMicrobial cell (Graz, Austria) · 2025Review
- A Novel Actin Binding Drug withAntimicrobial agents and chemotherapy · 2019Article
- A functional link between NADThe Journal of biological chemistry · 2018Article
- "High-Throughput Characterization of Region-Specific Mitochondrial Function and Morphology".Scientific reports · 2017Article
- Formaldehyde fixation is detrimental to actin cables in glucose-depletedMicrobial cell (Graz, Austria) · 2016Article
- Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor Expression.PloS one · 2015Article
- A Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase NAA10 Ser37Pro mutant.Molecular & cellular proteomics : MCP · 2014Article
- ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast.eLife · 2013Article
- Mdm20 stimulates polyQ aggregation via inhibiting autophagy through Akt-Ser473 phosphorylation.PloS one · 2013Article
- A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans.Molecular biology of the cell · 2011Article
- Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels.BMC genomics · 2010Article
- Structured digital tables on the Semantic Web: toward a structured digital literature.Molecular systems biology · 2010Article
- Properties of Nat4, an N(alpha)-acetyltransferase of Saccharomyces cerevisiae that modifies N termini of histones H2A and H4.Molecular and cellular biology · 2009Article
- The class V myosin motor protein, Myo2, plays a major role in mitochondrial motility in Saccharomyces cerevisiae.The Journal of cell biology · 2008Article
- Improper organization of the actin cytoskeleton affects protein synthesis at initiation.Molecular and cellular biology · 2007Article
- Roles of type II myosin and a tropomyosin isoform in retrograde actin flow in budding yeast.The Journal of cell biology · 2006Article
- The yeast actin cytoskeleton: from cellular function to biochemical mechanism.Microbiology and molecular biology reviews : MMBR · 2006Review
- The novel F-box protein Mfb1p regulates mitochondrial connectivity and exhibits asymmetric localization in yeast.Molecular biology of the cell · 2006Article
- Physiological importance and identification of novel targets for the N-terminal acetyltransferase NatB.Eukaryotic cell · 2006Article
- Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway.The Journal of cell biology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In Saccharomyces cerevisiae, the growing bud inherits a portion of the mitochondrial network from the mother cell soon after it emerges. Although this polarized transport of mitochondria is thought to require functions of the cytoskeleton, there are conflicting reports concerning the nature of the cytoskeletal element involved. Here we report the isolation of a yeast mutant, mdm20, in which both mitochondrial inheritance and actin cables (bundles of actin filaments) are disrupted. The MDM20 gene encodes a 93-kD polypeptide with no homology to other characterized proteins. Extra copies of TPM1, a gene encoding the actin filament-binding protein tropomyosin, suppress mitochondrial inheritance defects and partially restore actin cables in mdm20 delta cells. Synthetic lethality is also observed between mdm20 and tpm1 mutant strains. Overexpression of a second yeast tropomyosin, Tpm2p, rescues mutant phenotypes in the mdm20 strain to a lesser extent. Together, these results provide compelling evidence that mitochondrial inheritance in yeast is an actin-mediated process. MDM20 and TPM1 also exhibit the same pattern of genetic interactions; mutations in MDM20 are synthetically lethal with mutations in BEM2 and MYO2 but not SAC6. Although MDM20 and TPM1 are both required for the formation and/or stabilization of actin cables, mutations in these genes disrupt mitochondrial inheritance and nuclear segregation to different extents. Thus, Mdm20p and Tpm1p may act in vivo to establish molecular and functional heterogeneity of the actin cytoskeleton.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.