ArticleThe Journal of experimental medicine1997
Light chain usage in anti-double-stranded DNA B cell subsets: role in cell fate determination.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 69 citations in OpenAlex.
- The dsDNA, Anti-dsDNA Antibody, and Lupus Nephritis: What We Agree on, What Must Be Done, and What the Best Strategy Forward Could Be.Frontiers in immunology · 2019Review
- Hormonal milieu at time of B cell activation controls duration of autoantibody response.Journal of autoimmunity · 2014Article
- Regulation of basement membrane-reactive B cells in BXSB, (NZBxNZW)F1, NZB, and MRL/lpr lupus mice.Autoimmunity · 2013Article
- Immune enhancement by novel vaccine adjuvants in autoimmune-prone NZB/W F1 mice: relative efficacy and safety.BMC immunology · 2011Article
- Antigen is required for maturation and activation of pathogenic anti-DNA antibodies and systemic inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- BAFF overexpression promotes anti-dsDNA B-cell maturation and antibody secretion.Cellular immunology · 2010Article
- Anti-nuclear antibody reactivity in lupus may be partly hard-wired into the primary B-cell repertoire.Molecular immunology · 2009Article
- DNA-hydrolysing activity of IgG antibodies from the sera of patients with diseases caused by different bacterial infections.Journal of cellular and molecular medicine · 2009Article
- Molecular hallmarks of anti-chromatin antibodies associated with the lupus susceptibility locus, Sle1.Molecular immunology · 2009Article
- Pathogenic profiles and molecular signatures of antinuclear autoantibodies rescued from NZM2410 lupus mice.The Journal of experimental medicine · 2004Article
- Autoreactive responses to an environmental factor: 1. phthalate induces antibodies exhibiting anti-DNA specificity.Immunology · 2003Article
- Prolactin modulates the naive B cell repertoire.The Journal of clinical investigation · 2003Article
- Bromocriptine restores tolerance in estrogen-treated mice.The Journal of clinical investigation · 2000Article
- Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2.The Journal of experimental medicine · 2000Article
- Estrogen up-regulates Bcl-2 and blocks tolerance induction of naive B cells.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Regulation of anti-double-stranded DNA B cells in nonautoimmune mice: localization to the T-B interface of the splenic follicle.The Journal of experimental medicine · 1997Article
- Differential roles of estrogen receptors α and β in control of B-cell maturation and selection.Molecular medicine (Cambridge, Mass.)Article
- Selective regulation of autoreactive B cells by FcgammaRIIB.Journal of autoimmunityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Two major mechanisms for the regulation of autoreactive B cells that arise in the bone marrow are functional silencing (anergy) and deletion. Studies to date suggest that low avidity interactions between B cells and autoantigen lead to B cell silencing, whereas high avidity interactions lead to deletion. Anti-double stranded (ds) DNA antibodies represent a pathogenic autospecificity in Systemic Lupus Erythematosus (SLE). An understanding of their regulation is critical to an understanding of SLE. We now demonstrate in a transgenic model in which mice express the heavy chain of a potentially pathogenic anti-DNA antibody that antibody affinity for dsDNA does not alone determine the fate of anti-dsDNA B cells. B cells making antibodies with similar affinities for dsDNA are regulated differently, depending on light chain usage. A major implication of this observation is that dsDNA may not be the self antigen responsible for cell fate determinations of anti-dsDNA B cells. Light chain usage may determine antigenic cross-reactivity, and cross-reactive antigens may regulate B cells that also bind dsDNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.