ArticleProceedings of the National Academy of Sciences of the United States of America1997
Regular alcohol consumption mimics cardiac preconditioning by protecting against ischemia-reperfusion injury.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
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Who cites it
25 citing papers in PubMed, 111 citations in OpenAlex.
- White Wine Intake Reduces Mitochondrial Complex I-Derived ROS in the Male Rat Heart.Antioxidants (Basel, Switzerland) · 2026Article
- Non-Linear Relationship Between Alcohol Consumption and Neurological Outcomes in Patients With Out-of-Hospital Cardiac Arrest Presenting to the Emergency Department.Journal of Korean medical science · 2025Observational
- Life-threatening risk factors contribute to the development of diseases with the highest mortality through the induction of regulated necrotic cell death.Cell death & disease · 2025Review
- Purinergic signaling in myocardial ischemia-reperfusion injury.Purinergic signalling · 2023Review
- Cerebral Ischemia/Reperfusion Injury and Pharmacologic Preconditioning as a Means to Reduce Stroke-induced Inflammation and Damage.Neurochemical research · 2022Review
- Article
- [Effect of low-dose ethanol consumption on expression of nuclear factor-κB in diabetic rats with myocardial injury].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- Effects of chronic alcohol exposure on ischemia-reperfusion-induced acute kidney injury in mice: the role of β-arrestin 2 and glycogen synthase kinase 3.Experimental & molecular medicine · 2017Article
- Alcohol consumption mitigates apoptosis and mammalian target of rapamycin signaling in myocardium.Journal of the American College of Surgeons · 2014Article
- The adenosine transporter, ENT1, in cardiomyocytes is sensitive to inhibition by ethanol in a kinase-dependent manner: implications for ethanol-dependent cardioprotection and nucleoside analog drug cytotoxicity.Purinergic signalling · 2014Article
- Signaling pathways mediating alcohol effects.Current topics in behavioral neurosciences · 2013Review
- Moderate ethanol ingestion and cardiovascular protection: from epidemiologic associations to cellular mechanisms.Journal of molecular and cellular cardiology · 2012Review
- Antecedent ethanol attenuates cerebral ischemia/reperfusion-induced leukocyte-endothelial adhesive interactions and delayed neuronal death: role of large conductance, Ca2+-activated K+ channels.Microcirculation (New York, N.Y. : 1994) · 2010Article
- Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice.Journal of molecular and cellular cardiology · 2010Article
- Focus on: The cardiovascular system: what did we learn from the French (Paradox)?Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism · 2010Review
- PKC-permitted elevation of sarcolemmal KATP concentration may explain female-specific resistance to myocardial infarction.The Journal of physiology · 2009Article
- Alcohol in moderation, cardioprotection, and neuroprotection: epidemiological considerations and mechanistic studies.Alcoholism, clinical and experimental research · 2009Review
- Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2.Journal of molecular and cellular cardiology · 2009Article
- Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: role of NADPH oxidase-derived ROS.Free radical biology & medicine · 2007Article
- Antecedent ethanol ingestion prevents postischemic leukocyte adhesion and P-selectin expression by a protein kinase C-dependent mechanism.Digestive diseases and sciences · 2005Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Epidemiologic studies indicate that long-term alcohol consumption decreases the incidence of coronary disease and may improve outcome after myocardial infarction. Attenuation of ischemia-reperfusion injury after myocardial infarction improves survival. This study investigates the possibility that alcohol consumption can improve survival after myocardial infarction by reducing ischemia-reperfusion injury. Hearts were isolated from guinea pigs after drinking ethanol for 3-12 weeks and subjected to global ischemia and reperfusion. Hearts from animals drinking ethanol showed improved functional recovery and decreased myocyte damage when compared with controls. Adenosine A1 receptor blockade abolished the protection provided by ethanol consumption. These findings indicate that long-term alcohol consumption reduces myocardial ischemia-reperfusion injury and that adenosine A1 receptors are required for this protective effect of ethanol. This cardioprotective effect of long-term alcohol consumption mimics preconditioning and may, in part, account for the beneficial effect of moderate drinking on cardiac health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.