ArticleProceedings of the National Academy of Sciences of the United States of America1997
Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 178 citations in OpenAlex.
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- Targeting Tyrosine Kinases in Acute Myeloid Leukemia: Why, Who and How?International journal of molecular sciences · 2019Review
- Three Tyrosine Residues in the Erythropoietin Receptor Are Essential for Janus Kinase 2 V617F Mutant-induced Tumorigenesis.The Journal of biological chemistry · 2017Article
- Epo-induced erythroid maturation is dependent on Plcγ1 signaling.Cell death and differentiation · 2015Article
- Kit transduced signals counteract erythroid maturation by MAPK-dependent modulation of erythropoietin signaling and apoptosis induction in mouse fetal liver.Cell death and differentiation · 2015Article
- Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5.PloS one · 2015Article
- Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors.Journal of cellular and molecular medicine · 2013Article
- Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.Human molecular genetics · 2013Article
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- The erythropoietin receptor: molecular structure and hematopoietic signaling pathways.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2011Review
- Erythropoietin-driven proliferation of cells with mutations in the tumor suppressor gene TSC2.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Erythropoietin receptor response circuits.Current opinion in hematology · 2010Review
- Advances in understanding the pathogenesis of primary familial and congenital polycythaemia.British journal of haematology · 2010Review
- Polycythemia vera erythroid precursors exhibit increased proliferation and apoptosis resistance associated with abnormal RAS and PI3K pathway activation.Experimental hematology · 2009Article
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- Molecular target approaches in head and neck cancer: epidermal growth factor receptor and beyond.Seminars in radiation oncology · 2009Review
- Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions.Molecular systems biology · 2009Article
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- Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Homodimerization of the erythropoietin (EPO) receptor (EPO-R) in response to EPO binding transiently activates the receptor-associated protein tyrosine kinase JAK2. Tyrosine phosphorylation of the EPO-R creates "docking sites" for SH2 domain(s) in signaling molecules such as the protein tyrosine phosphatases SH-PTP1 and SH-PTP2, phosphoinositide 3-kinase (PI3 kinase), and STAT5. However, little is known about the specific intracellular signals essential for proliferation and differentiation of erythroid progenitors. Here we show that an EPO-R containing only one cytosolic (phospho)tyrosine residue, Y479, induces a signal transduction pathway sufficient for proliferation and differentiation of fetal liver progenitors of erythroid colony-forming units from EPO-R(-/-) mice as well as for proliferation of cultured hematopoietic cells. This cascade involves sequential EPO-induced recruitment of PI3 kinase to the EPO-R and activation of mitogen-activated protein kinase activity, independent of the Shc/Grb2-adapter pathway and of STAT5. Protein kinase C epsilon may be one of the mediators connecting PI3 kinase with the mitogen-activated protein kinase signaling cascade. Our results identify a signaling cascade important in vivo for erythroid cell proliferation and differentiation.
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