ArticleProceedings of the National Academy of Sciences of the United States of America1997
Subunit arrangement in the human 20S proteasome.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 120 citations in OpenAlex.
- Carmaphycin B-Based Proteasome Inhibitors to Treat Human African Trypanosomiasis: Structure-Activity Relationship andACS infectious diseases · 2024Article
- Structural Analysis of the 20S Proteasome Using Native Mass Spectrometry and Ultraviolet Photodissociation.Journal of proteome research · 2024Article
- Article
- Interactions Between the Ubiquitin-Proteasome System, Nrf2, and the Cannabinoidome as Protective Strategies to Combat Neurodegeneration: Review on Experimental Evidence.Neurotoxicity research · 2024Review
- The proteasome as a drug target for treatment of parasitic diseases.Advances in parasitology · 2024Review
- The subversion of toll-like receptor signaling by bacterial and viral proteases during the development of infectious diseases.Molecular aspects of medicine · 2022Review
- MG132 protects against lung injury following brain death in rats.Experimental and therapeutic medicine · 2022Article
- Activating IL-6/STAT3 Enhances Protein Stability of Proteasome 20SBioMed research international · 2022Article
- Reactive Oxygen Species in Metabolic and Inflammatory Signaling.Circulation research · 2018Review
- Computational Approaches for the Discovery of Human Proteasome Inhibitors: An Overview.Molecules (Basel, Switzerland) · 2016Review
- Surface induced dissociation yields substructure ofInternational journal of mass spectrometry · 2015Article
- Dysregulation of ubiquitin-proteasome pathway and apolipoprotein A metabolism in sickle cell disease-related pulmonary arterial hypertension.Pulmonary circulation · 2013Article
- Redox control of 20S proteasome gating.Antioxidants & redox signaling · 2012Article
- Circulating extracellular proteasome in the cerebrospinal fluid: a study on concentration and proteolytic activity.Journal of molecular neuroscience : MN · 2012Article
- Distinct proteasome subpopulations in the alveolar space of patients with the acute respiratory distress syndrome.Mediators of inflammation · 2012Article
- A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease.Biochimica et biophysica acta · 2009Review
- BCR-ABL fusion regions as a source of multiple leukemia-specific CD8+ T-cell epitopes.Leukemia · 2006Article
- Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation.Molecular and cellular biology · 2001Article
- The ubiquitin-proteasome pathway and proteasome inhibitors.Medicinal research reviews · 2001Review
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In human 20S proteasomes two copies of each of seven different alpha-type and seven different beta-type subunits are assembled to form a stack of four seven-membered rings, giving the general structure alpha(1-7), beta(1-7), beta(1-7), alpha(1-7). By means of immunoelectron microscopy and chemical crosslinking of neighboring subunits, we have determined the positions of the individual subunits in the proteasome. The topography shows that for the trypsin-like, the chymotrypsin-like, and the postglutamyl cleaving activities, the pairs of beta type subunits, which are thought to form active sites, are nearest neighbors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.