ArticleProceedings of the National Academy of Sciences of the United States of America1997
Nucleosome-mediated synergism between transcription factors on the mouse mammary tumor virus promoter.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 88 citations in OpenAlex.
- Increased nuclear factor I-mediated chromatin access drives transition to androgen receptor splice variant dependence in prostate cancer.Cell reports · 2025Article
- Proteomic analysis reveals molecular changes following genetic engineering in Chlamydomonas reinhardtii.BMC microbiology · 2024Article
- Profiling Accessible Chromatin and Nucleosomes in the Mammalian Genome.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Nucleosome Positioning on Episomal Human Papillomavirus DNA in Cultured Cells.Pathogens (Basel, Switzerland) · 2021Article
- 90 YEARS OF PROGESTERONE: Molecular mechanisms of progesterone receptor action on the breast cancer genome.Journal of molecular endocrinology · 2020Review
- NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices.Nature cell biology · 2020Article
- Positional specificity of different transcription factor classes within enhancers.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Histone availability as a strategy to control gene expression.RNA biology · 2017Review
- Hormone-induced repression of genes requires BRG1-mediated H1.2 deposition at target promoters.The EMBO journal · 2016Article
- The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation.Molecular cell · 2016Article
- Theoretical estimates of exposure timescales of protein binding sites on DNA regulated by nucleosome kinetics.Nucleic acids research · 2016Article
- Pioneer transcription factors in cell reprogramming.Genes & development · 2014Review
- The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer.The Journal of biological chemistry · 2014Article
- Structural constraints in collaborative competition of transcription factors against the nucleosome.Journal of molecular biology · 2011Article
- Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists.BMC cancer · 2010Article
- Characterization of cis elements of the probasin promoter necessary for prostate-specific gene expression.The Prostate · 2010Article
- Article
- Erk signaling and chromatin remodeling in MMTV promoter activation by progestins.Nuclear receptor signaling · 2009Review
- DNA-binding specificity and in vivo targets of Caenorhabditis elegans nuclear factor I.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- A composite intronic element directs dynamic binding of the progesterone receptor and GATA-2.Molecular endocrinology (Baltimore, Md.) · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In unstimulated mammalian cells and in Saccharomyces cerevisiae, the mouse mammary tumor virus (MMTV) promoter is silent and organized into positioned nucleosomes, one of which encompasses the binding sites for glucocorticoid receptor (GR) and nuclear factor I (NFI). Glucocorticoid induction in vivo involves a functional synergism between GR and NFI and simultaneous occupancy of the promoter sites for both proteins that cannot be reproduced on naked DNA. The role of chromatin in the process of induction was investigated by manipulating the nucleosome density in yeast strains carrying a regulated histone H4 gene. Following depletion of nucleosomes, independent transactivation by NFI or by GR, as well as binding of the individual proteins to the MMTV promoter, were enhanced, in agreement with a repressive function of nucleosomes. In contrast, NFI-dependent hormone induction of the promoter and the simultaneous binding of receptor and NFI were compromised by nucleosome depletion. This effect could be partly mediated by a cryptic binding site for the receptor that is functional only in the nucleosomal context. Thus, positioned nucleosomes do not only account for constitutive repression of the MMTV promoter, but also participate in induction by mediating cooperative binding and functional synergism between GR and NFI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.