ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Second messengers, trafficking-related proteins, and amino acid residues that contribute to the functional regulation of the rat brain GABA transporter GAT1.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 139 citations in OpenAlex.
- Electrophysiology of ionotropic GABA receptors.Cellular and molecular life sciences : CMLS · 2021Review
- Regulation of Glutamate, GABA and Dopamine Transporter Uptake, Surface Mobility and Expression.Frontiers in cellular neuroscience · 2021Review
- Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology.Advances in experimental medicine and biology · 2021Review
- VPACBritish journal of pharmacology · 2017Article
- Manganese toxicity in the central nervous system: the glutamine/glutamate-γ-aminobutyric acid cycle.Journal of internal medicine · 2013Review
- Vesicular and plasma membrane transporters for neurotransmitters.Cold Spring Harbor perspectives in biology · 2012Review
- Inhibition of Activity of GABA Transporter GAT1 by δ-Opioid Receptor.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Plasticity of vagal brainstem circuits in the control of gastrointestinal function.Autonomic neuroscience : basic & clinical · 2011Review
- Plasticity of vagal brainstem circuits in the control of gastric function.Neurogastroenterology and motility · 2010Article
- Intelligence in Williams Syndrome is related to STX1A, which encodes a component of the presynaptic SNARE complex.PloS one · 2010Article
- Enhanced tonic GABAA inhibition in typical absence epilepsy.Nature medicine · 2009Article
- Sec24- and ARFGAP1-dependent trafficking of GABA transporter-1 is a prerequisite for correct axonal targeting.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Calcium/calmodulin-dependent kinase II regulates the interaction between the serotonin transporter and syntaxin 1A.Neuropharmacology · 2008Article
- Analysis of knock-out mice to determine the role of HPC-1/syntaxin 1A in expressing synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Activation of classical protein kinase C reduces the expression of human cationic amino acid transporter 3 (hCAT-3) in the plasma membrane.The Biochemical journal · 2006Article
- Calpain sensitive regions in the N-terminal cytoplasmic domains of glycine transporters GlyT1A and GlyT1B.Neurochemical research · 2005Article
- Osmotic regulation of renal betaine transport: transcription and beyond.Pflugers Archiv : European journal of physiology · 2004Review
- Musings on the wanderer: what's new in our understanding of vago-vagal reflexes? III. Activity-dependent plasticity in vago-vagal reflexes controlling the stomach.American journal of physiology. Gastrointestinal and liver physiology · 2003Review
- Glutamate modulation of GABA transport in retinal horizontal cells of the skate.The Journal of physiology · 2003Article
- Expression and functional characterization of GABA transporters in crayfish neurosecretory cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Recent evidence indicates that several members of the Na+-coupled transporter family are regulated, and this regulation in part occurs by redistribution of transporters between intracellular locations and the plasma membrane. We elucidate components of this process for both wild-type and mutant GABA transporters (GAT1) expressed in Xenopus oocytes using a combination of uptake assays, immunoblots, and electrophysiological measurements of membrane capacitance, transport-associated currents, and GAT1-specific charge movements. At low GAT1 expression levels, activators of protein kinase C (PKC) induce redistribution of GAT1 from intracellular vesicles to the plasma membrane; at higher GAT1 expression levels, activators of PKC fail to induce this redistribution. However, coinjection of total rat brain mRNA with GAT1 permits PKC-mediated modulation at high transporter expression levels. This effect of brain mRNA on modulation is mimicked by coinjection of syntaxin 1a mRNA and is eliminated by injecting synaptophysin or syntaxin antisense oligonucleotides. Additionally, botulinum toxins, which inactivate proteins involved in vesicle release and recycling, reduce basal GAT1 expression and prevent PKC-induced translocation. Mutant GAT1 proteins, in which most or all of a leucine heptad repeat sequence was removed, display altered basal distribution and lack susceptibility to modulation by PKC, delineating one region of GAT1 necessary for its targeting. Thus, functional regulation of GAT1 in oocytes occurs via components common to transporters and to trafficking in both neural and non-neural cells, and suggests a relationship between factors that control neurotransmitter secretion and the components necessary for neurotransmitter uptake.
Indexed as
Identifiers
9096133PMC6573650W2147739392What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.