ArticleMammalian genome : official journal of the International Mammalian Genome Society1997
The mouse chromosome 7 distal imprinting domain maps to G-bands F4/F5.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- A genomic imprinting defect in mice traced to a single gene.Genetics · 2010Article
- Article
- A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip.Nucleic acids research · 2010Article
- Postnatal survival of mice with maternal duplication of distal chromosome 7 induced by a Igf2/H19 imprinting control region lacking insulator function.PLoS genetics · 2010Article
- Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10.Molecular and cellular biology · 2008Article
- Allele-specific demethylation at an imprinted mammalian promoter.Nucleic acids research · 2007Article
- Chromosome-wide identification of novel imprinted genes using microarrays and uniparental disomies.Nucleic acids research · 2006Article
- Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes.Genes & development · 1997Article
- A candidate model for Angelman syndrome in the mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
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Authors and funding
4 authors.
Funding
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Abstract
Mouse Chromosome (Chr) 7 distal to band F3 on the physical map is known to be subject to imprinting, maternal duplication (MatDp) of the region leading to a late embryonic lethality, while paternal duplication (PatDp) causes death in utero before 11.5 dpc. Using a new mouse reciprocal translocation T(7;11)65H to produce MatDp for distal Chr 7, we have mapped the region subject to imprinting more precisely to bands 7F4/F5 on the cytogenetic map. Fluorescence in situ hybridization (FISH) studies on mitotic and meiotic chromosomes of a T65H heterozygote show that the imprinted gene Igf2 is located in the same region. This was confirmed by the finding that embryos with MatDp of bands 7F4/F5 did not express Igf2. We suggest that other members of the imprinted domain containing Igf2, namely Mash2, H19, Ins2, and p57(K1P2), are also located in 7F4/F5 and that some or all of these genes may be responsible for the two imprinting lethalities seen with MatDp and PatDp for this region.
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