ArticleMammalian genome : official journal of the International Mammalian Genome Society1997
Linkage map and congenic strains to localize blood pressure QTL on rat chromosome 10.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Nitric oxide and salt resistance in Dahl rats: no role of inducible NO synthase.Physiological research · 2023Article
- Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans.Physiological reviews · 2017Review
- Epigenetics and the control of the collecting duct epithelial sodium channel.Seminars in nephrology · 2013Review
- Molecular mechanisms of experimental salt-sensitive hypertension.Journal of the American Heart Association · 2012Article
- Af17 deficiency increases sodium excretion and decreases blood pressure.Journal of the American Society of Nephrology : JASN · 2011Article
- Mitochondrial polymorphisms in rat genetic models of hypertension.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- A genome-wide SNP panel for mapping and association studies in the rat.BMC genomics · 2008Article
- Congenic mapping of a blood pressure QTL region on rat chromosome 10 using the Dahl salt-sensitive rat with introgressed alleles from the Milan normotensive strain.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Article
- BAC resources for the rat genome project.Genome research · 2004Article
- Further dissection of a genomic locus associated with behavioral activity in the Wistar-Kyoto hyperactive rat, an animal model of hyperkinesis.Molecular psychiatry · 2003Article
- Critique of "chromosome 17 and the inducible nitric oxide synthase gene in human essential hypertension" by Rutherford et al., Human Genetics, published online September 2001.Human genetics · 2002Article
- Strategy for uncovering complex determinants of hypertension using animal models.Current hypertension reports · 2000Review
- Genetic dissection of X-linked interspecific hybrid placental dysplasia in congenic mouse strains.Genetics · 1999Article
- Analysis of the mesotelencephalic dopamine system by quantitative-trait locus introgression.Neurochemical research · 1998Article
- Construction of a double congenic strain to prove an epistatic interaction on blood pressure between rat chromosomes 2 and 10.The Journal of clinical investigation · 1998Article
- Chromosomal assignment of nineteen rat microsatellite markers to various chromosomes by linkage analysis.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- Linkage mapping of rat chromosome markers generated from chromosome-sorted DNA.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- Mapping of rat chromosome 5 markers generated from chromosome-sorted DNA.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Use of animal models to search for candidate genes associated with essential hypertension.Current hypertension reportsReview
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6 authors.
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Abstract
Our purposes were to develop a linkage map for rat Chromosome (Chr) 10, using chromosome-sorted DNA, and to construct congenic strains to localize blood pressure quantitative trait loci (QTL) on Chr 10 with the map. The linkage mapping panel consisted of three F2 populations totaling 418 rats. Thirty-two new and 29 known microsatellite markers were placed on the map, which spanned 88.9 centiMorgans (cM). The average distance between markers was 1.46 cM. No markers were separated by more than 6.8 cM. Four congenic strains were constructed by introgressing various segments of Chr 10 from the Milan normotensive strain (MNS) onto the background of the Dahl salt-sensitive (S) strain. A blood pressure QTL with a strong effect on blood pressure (35-42 mm Hg) when expressed on the S background was localized to a 31-cM region between D10Mco6 and D10Mcol. The region does not include the locus for inducible nitric oxide synthase (Nos2), which had been considered to be a candidate locus for the QTL.
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