ArticleMolecular and cellular biochemistry1996
Muscle ubiquinone in male effort angina patients.
Article in Molecular and cellular biochemistry, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Muscle metabolism and quality (MQI) in prediabetic sedentary man.Molecular and cellular biochemistry · 1998Article
- Muscle fibers, ubiquinone and exercise capacity in effort angina.Molecular and cellular biochemistry · 1996Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seven (7) males with effort angina and listed for coronary by-pass surgery had muscle biopsies taken from their vastus lateralis muscle for determination of muscle fiber types (%ST), ubiquinone (vitamin Q, UQ), oxidative and fermentative enzyme activities. Graded cycle ergometer exercise to determine intensities corresponding to onset of blood lactate accumulation set to 2.0 mmol x l-1 (WOBLA) and symptom limited exercise ('maximal', WSL) were also undertaken. WOBLA was positively related to %ST (r = 0.92, p < 0.001). %ST was on the other hand inversely related to UQ (r = -0.82, p < 0.05), the heart specific LD subunit LD-H (r = -0.96, p < 0.001), the isozyme LD3 as the fraction of LD (%LD3) (r = -0.93, p < 0.01), and the CK isozyme CKMB as the fraction of CK (%CKMB) (r = -0.88, p < 0.05). It was suggested that muscle UQ depletion in the patients was related to molecular oxygen and free oxygen radical formation. The lack of antioxidants then caused a radical trauma specifically to the ST fiber and their mitochondria. This could be a cause and-effect explanation for the selective ST fiber downregulation in effort angina and heart failure in general.
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