Evidence map›Paper›PMID 9094701›Full record

ArticleJournal of virology1997

Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice.

R J Gulizia, R G Collman, J A Levy, D Trono, D E Mosier

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. The Role of L-Selectin in HIV Infection.Frontiers in microbiology · 2021
    Review
  5. Review
  6. HIV-Resistant and HIV-Specific CAR-Modified CD4Molecular therapy : the journal of the American Society of Gene Therapy · 2020
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
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  13. Article
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  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

R J GuliziaDepartment of Immunology-IMM7, The Scripps Research Institute, La Jolla, California 92037, USA.
R G Collman
J A Levy
D Trono
D E Mosier
Scripps Research Institute · US

Funding

HIV-INFECTED HU-SCID MICE AS MODELS FOR AIDS THERAPYR01AI029182 · NIAID · SCRIPPS RESEARCH INSTITUTE · PI MOSIER, DONALD E · 1989 to 1998
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HIV INFECTED HU-SCID MICE AS MODELS FOR AIDS THERAPYR21AI029182 · NIAID · SCRIPPS RESEARCH INSTITUTE · PI MOSIER, DONALD E · 1998 to 1998
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NIAID NIH HHS AI-29182
6 · The paper itself

Abstract

The pathogenicity of four human immunodeficiency virus type 1 (HIV-1) isolates with nef deleted for SCID mice repopulated with human peripheral blood leukocytes (hu-PBL-SCID mice) was studied. Deletion of nef led to a substantial reduction in CD4-positive T-cell depletion and delayed kinetics of plasma viremia in infected hu-PBL-SCID mice. Deletion of the nef gene impacts both the efficiency of primary infection and the cytopathicity of virus for infected CD4-positive T cells in this animal model of HIV-1 infection.

Indexed as

HIV-1Acquired Immunodeficiency SyndromeAnimalsCD4-Positive T-LymphocytesGene DeletionGenes, nefHumansLeukocytesMiceMice, SCIDRNA, ViralRNA, Viral

Identifiers

PMID9094701
PMCPMC191576
OpenAlexW2096570932

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.