Evidence map›Paper›PMID 9094651›Full record

ArticleJournal of virology1997

Cells transformed by a v-Myb-estrogen receptor fusion differentiate into multinucleated giant cells.

U Engelke, D M Wang, J S Lipsick

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Transformation by v-Myb.Oncogene · 1999
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

U EngelkeDepartment of Pathology, Stanford University School of Medicine, California 94305-5324, USA.
D M Wang
J S Lipsick
Stanford University · US

Funding

TUMOR BIOLOGYT32CA009151 · NCI · STANFORD UNIVERSITY · PI CLEARY, MICHAEL L · 1985 to 2014
$5.5M
MECHANISM OF TRANSFORMATION BY THE V-MYB ONCOGENESR01CA043592 · NCI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI LIPSICK, JOSEPH STEVEN · 1987 to 2005
$1.5M
NCI NIH HHS R01 CA43592NCI NIH HHS T32 CA09151
6 · The paper itself

Abstract

In order to make conditional alleles of the v-myb oncogene, we constructed and tested avian retroviruses which produce a number of different fusion proteins between v-Myb and the human estrogen receptor (ER). We found that the portion of the ER used in making these fusions profoundly affected their transcriptional activation. However, all the fusions tested were only weakly transforming in embryonic yolk sac assays and there was no direct correlation between the level of transcriptional activation and strength of oncogenic transformation. Nevertheless, transformation by a v-Myb-ER fusion was estrogen dependent, and upon withdrawal of the hormone, monocytic-lineage cells differentiated into multinucleated giant cells. Surprisingly, the withdrawal of estrogen caused a dramatic increase in the stability of the fusion protein, although it remained unable to promote cell growth or block differentiation.

Indexed as

Cell Transformation, NeoplasticAnimalsCell DifferentiationEstrogensOncogene Proteins v-mybQuailReceptors, EstrogenRecombinant Fusion ProteinsRetroviridae Proteins, OncogenicTranscriptional ActivationEstrogensOncogene Proteins v-mybReceptors, EstrogenRecombinant Fusion ProteinsRetroviridae Proteins, Oncogenic

Identifiers

PMID9094651
PMCPMC191526
OpenAlexW2119042598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.