ArticleJournal of virology1997
Human immunodeficiency virus type 1 infection of cells and tissues from the upper and lower human female reproductive tract.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 128 citations in OpenAlex.
- Article
- Breaching the Barrier: Investigating Initial Herpes Simplex Viral Infection and Spread in Human Skin and Mucosa.Viruses · 2024Review
- HIV-1 transmission: modelling and direct visualization in the third dimension.Microscopy (Oxford, England) · 2023Review
- Article
- Lactate Suppresses Retroviral Transduction in Cervical Epithelial Cells through DNA-PKcs Modulation.International journal of molecular sciences · 2021Article
- Article
- ART influences HIV persistence in the female reproductive tract and cervicovaginal secretions.The Journal of clinical investigation · 2016Article
- Chemokine-mediated immune responses in the female genital tract mucosa.Immunology and cell biology · 2015Review
- Distinct characteristics of endometrial and decidual macrophages and regulation of their permissivity to HIV-1 infection by SAMHD1.Journal of virology · 2015Article
- Interactions between HIV-1 and mucosal cells in the female reproductive tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Review
- Acting locally: innate mucosal immunity in resistance to HIV-1 infection in Kenyan commercial sex workers.Mucosal immunology · 2014Article
- Article
- Mucosal immunity in the female genital tract, HIV/AIDS.BioMed research international · 2014Review
- Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells.The Journal of infectious diseases · 2013Article
- BLT humanized mice as model to study HIV vaginal transmission.The Journal of infectious diseases · 2013Review
- A systems biology examination of the human female genital tract shows compartmentalization of immune factor expression.Journal of virology · 2013Article
- Innate and adaptive anti-HIV immune responses in the female reproductive tract.Journal of reproductive immunology · 2013Review
- Use of human mucosal tissue to study HIV-1 pathogenesis and evaluate HIV-1 prevention modalities.Current HIV/AIDS reports · 2013Review
- Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection.Journal of reproductive immunology · 2011Review
- Endometrial histopathology in patients with laparoscopic proven salpingitis and HIV-1 infection.Infectious diseases in obstetrics and gynecology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Viable tissue sections and isolated cell cultures from the human fallopian tube, uterus, cervix, and vaginal mucosa were examined for susceptibility to infection with human immunodeficiency virus type 1 (HIV-1). We examined infectivity by using the monocytotropic strain HIV-1(JR-FL) and several primary isolates of HIV-1 obtained from infected neonates. HIV-1 infection was measured by p24 production in short-term culture and by immunofluorescence detection of HIV-1 Nef and p24 proteins by laser scanning confocal microscopy. Three-color immunofluorescence was used to phenotype HIV-infected cells within tissue sections from each site. Our findings indicate that epithelial, stromal, and dendritic cells and cells with CD14+ CD4+, CD14-CD4-, and CD4+ CD14- phenotypes from the female reproductive tract are infectable with HIV-1. Of importance is the finding that tissues from the upper reproductive tract are susceptible to infection with HIV-1. Moreover, tissue samples from women in all stages of the menstrual cycle, including postmenopausal women (inactive), could be infected with HIV-1. Female reproductive tract cells required a minimum of 60 min of exposure to HIV-1 in order for infection to occur, in contrast to peripheral blood lymphocytes, which became infected after being exposed to HIV-1 for only 1 min. These findings demonstrate that HIV-1 can infect cells and tissues from different sites within the female reproductive tract and suggest that multiple cell types, including epithelial cells, may be targets for the initial infection by HIV-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.