ArticleGenetics1997
Genomic organization and evolution of alternative exons in a Drosophila calcium channel gene.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Bichromatic Exon-Reporters Reveal Voltage-Gated CaeNeuro · 2025Article
- Evolutionary and ontogenetic changes in RNA editing in human, chimpanzee, and macaque brains.RNA (New York, N.Y.) · 2013Article
- When population and evolutionary genetics met behaviour.Memorias do Instituto Oswaldo Cruz · 2013Review
- Ca(v)2 channels mediate low and high voltage-activated calcium currents in Drosophila motoneurons.The Journal of physiology · 2012Article
- Editing of neurotransmitter receptor and ion channel RNAs in the nervous system.Current topics in microbiology and immunology · 2012Review
- Evolutionary dynamics of U12-type spliceosomal introns.BMC evolutionary biology · 2010Article
- Tuning of RNA editing by ADAR is required in Drosophila.The EMBO journal · 2005Article
- Genetic divergence in the cacophony IVS6 intron among five Brazilian populations of Lutzomyia longipalpis.Journal of molecular evolution · 2004Article
- The impact of splice isoforms on voltage-gated calcium channel alpha1 subunits.The Journal of physiology · 2004Review
- Article
- Micro-processing events in mRNAs identified by DHPLC analysis.Nucleic acids research · 2002Article
- Functional diversity in neuronal voltage-gated calcium channels by alternative splicing of Ca(v)alpha1.Molecular neurobiology · 2002Review
- Synaptic calcium-channel function in Drosophila: analysis and transformation rescue of temperature-sensitive paralytic and lethal mutations of cacophony.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- The properties of a tRNA-specific adenosine deaminase from Drosophila melanogaster support an evolutionary link between pre-mRNA editing and tRNA modification.Molecular and cellular biology · 2000Article
- Courtship and visual defects of cacophony mutants reveal functional complexity of a calcium-channel alpha1 subunit in Drosophila.Genetics · 1998Article
- Genetic and developmental characterization of Dmca1D, a calcium channel alpha1 subunit gene in Drosophila melanogaster.Genetics · 1998Article
- Analysis of temperature-sensitive mutants reveals new genes involved in the courtship song of Drosophila.Genetics · 1998Article
- Progressive ataxia due to a missense mutation in a calcium-channel gene.American journal of human genetics · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The genomic organization of a gene coding for an alpha 1 subunit of a voltage-gated calcium channel of Drosophila melanogaster (Dmca IA) was determined. Thirty-four exons, distributed over 45 kb of genomic sequence, have been identified and mapped, including exons in three regions involved in alternative splicing and new sites potentially involved in RNA editing. The comparison of the intron/exon boundaries of this channel with a mammalian counterpart shows that the genomic structure of these two genes has remained fairly similar during evolution, with more than half of the Drosophila intron positions being perfectly conserved compared to the human channel. Phylogenetic analysis of the mutually exclusive alternative exons revealed that they have diverged considerably. It is suggested that this divergence, rather than reflecting evolutionary age, is the likely result of accelerated rates of evolution following duplication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.